Chemical structures, biosynthesis, bioactivities, biocatalysis and semisynthesis of tobacco cembranoids: An overview

文献类型： 外文期刊

第一作者： Yan, Ning

作者： Yan, Ning;Du, Yongmei;Liu, Xinmin;Zhang, Hongbo;Liu, Yanhua;Zhang, Peng;Gong, Daping;Zhang, Zhongfeng

作者机构：

关键词： Tobacco cembranoids;Chemical structures;Biosynthesis;Bioactivities;Biocatalysis;Semisynthesis

期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：5.645； 五年影响因子：5.749 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Cembranoids, 14-membered carbocyclic diterpenes composed of four isoprene units, are mainly found in plants of the Nicotiana and Pinus genera, as well as in soft coral and other marine organisms. We summarise the chemical structures of the eighty-seven naturally occurring tobacco cembranoids (1-52), nor-cembranoids (53-74), seco-cembranoids (75-82) and cyclised cembranoids (83-87) reported to date. The most prevalent cembranoids in tobacco are (1S,2E,4S,7E,11E)-cembra-2,7,11-triene-4,6-diol (1) and (1S,2E,412,7E,11E)-cembra-2,7,11-triene-4,6-diol (2), which are biosynthesised in the plastid from the reactions of geranylgeranyl diphosphate with cembrantrien-ol synthase and cytochrome P450 hydroxylase via the 2-C-methyl-D-erythritol-4-phosphate metabolic pathway. The accumulation of cembranoids in tobacco is affected by genetic and environmental factors, including fertiliser, water and light exposure, soil-type and temperature. Tobacco-derived cembranoids are known to display antifungal, antibacterial, anti-human immunodeficiency virus, anti-tumour and neuroprotective properties. A large number of biologically active (primarily anti-invasive, anti-prolifeiative, anti-migratory and neuroprotective) compounds have been prepared from the semisynthesis of tobacco cembranoids, many via biocatalytic methods. The documented bioactivities of tobacco cembranoids make them excellent templates for the future development of drugs to treat cancer, AIDS, Alzheimer's disease, Parkinson's disease, stroke and other neurodegenerative diseases. These findings indicated that although tobacco has long been associated with negative effects on human health, it may ultimately be able to play a therapeutic role. (c) 2015 Elsevier B.V. All rights reserved.

分类号： S5

  • 相关文献

[1]Simultaneous characterization of chemical structures and bioactivities of citrus-derived components using SERS barcodes. Zhang, Ye,Zhao, Chengying,Tian, Guifang,Lu, Chang,Li, Yuzhi,Zheng, Jinkai,He, Lili,Xiao, Hang. 2018

[2]Solanesol: a review of its resources, derivatives, bioactivities, medicinal applications, and biosynthesis. Yan, Ning,Liu, Yanhua,Gong, Daping,Du, Yongmei,Zhang, Huaibao,Zhang, Zhongfeng. 2015

[3]Effects of processing on phytochemical profiles and biological activities for production of sorghum tea. Wu, Li,Huang, Zhaohui,Qin, Peiyou,Ren, Guixing,Huang, Zhaohui.

[4]Secondary metabolites of rice sheath blight pathogen Rhizoctonia solani Kuhn and their biological activities. Xu Liang,Wang Xiao-han,Luo Rui-ya,Lu Shi-qiong,Guo Ze-jian,Wang Ming-an,Zhou Li-gang,Liu Yang. 2015

[5]Enhancement of botrallin and TMC-264 production in liquid culture of endophytic fungus Hyalodendriella sp Ponipodef12 after treatments with metal ions. Luo, Haiyu,Xu, Dan,Xie, Rushan,Zhang, Xuping,Wang, Jian,Dong, Xuejiao,Lai, Daowan,Zhou, Ligang,Liu, Yang. 2016

[6]Synthesis and Bioactivity Studies of 2,3-Disubstituted Quinazolin-4(3H)-one. Liu Kechang,Wang Yi,Zhang Hao,Liu Ruiquan,Li Qibo,Liu Shangzhong,Wang Qingmin,Li Yongqiang,Rui Changhui. 2014

[7]Phytochemicals and bioactivities of Paris species. Zhang, Jin-Yu,Wang, Yuan-Zhong,Zhao, Yan-Li,Yang, Shao-Bing,Zuo, Zhi-Tian,Yang, Mei-Quan,Zhang, Ji,Yang, Wei-Ze,Yang, Tian-Mei,Jin, Hang.

[8]Enantio-selective preparation of (S)-1-phenylethanol by a novel marine GDSL lipase MT6 with reverse stereo-selectivity. Deng, Dun,Zhang, Yun,Sun, Aijun,Hu, Yunfeng,Deng, Dun,Zhang, Yun,Sun, Aijun,Hu, Yunfeng,Deng, Dun,Hu, Yunfeng. 2016

[9]Production of Adipic Acid from Sugar Beet Residue by Combined Biological and Chemical Catalysis. Zhang, Hongfang,Su, Xiaoyun,Ang, Ee Lui,Zhao, Huimin,Li, Xiukai,Zhang, Yugen,Su, Xiaoyun,Zhao, Huimin,Zhao, Huimin,Zhao, Huimin. 2016

[10]Lipase Immobilization on Hyper-Cross-Linked Polymer-Coated Silica for Biocatalytic Synthesis of Phytosterol Esters with Controllable Fatty Acid Composition. Zheng, Ming-Ming,Huang, Feng-Hong,Wang, Lian,Guo, Ping-Mei,Deng, Qian-Chun,Zheng, Ming-Ming,Huang, Feng-Hong,Wang, Lian,Guo, Ping-Mei,Deng, Qian-Chun,Lu, Yong,Feng, Yu-Qi.

[11]Selective hydrolysis by commercially available hesperidinase for isoquercitrin production. Wang, Jun,Ma, Yan-Long,Xia, Rui,Sun, Guo-Xia,Wu, Fu-An,Wang, Jun,Wu, Xiang-Yang,Yu, Liang,Wu, Fu-An,Yu, Liang.

[12]Structured lipids enriched with unsaturated fatty acids produced by enzymatic acidolysis of silkworm pupae oil using oleic acid. Zhao, Xing-Yu,Wang, Xu-Dong,Liu, Xi,Zhu, Wei-Jie,Mei, Yi-Yuan,Li, Wen-Wen,Wang, Jun,Wang, Jun.

[13]Immobilization of Candida rugosa lipase on hydrophobic/strong cation-exchange functional silica particles for biocatalytic synthesis of phytosterol esters. Zheng, Ming-Ming,Dong, Ling,Guo, Ping-Mei,Deng, Qian-Chun,Li, Wen-Lin,Huang, Feng-Hong,Lu, Yong,Feng, Yu-Qi.

[14]A novel chemoenzymatic synthesis of propyl caffeate using lipase-catalyzed transesterification in ionic liquid. Pang, Na,Gu, Shuang-Shuang,Wang, Jun,Cui, Hong-Sheng,Wang, Fang-Qin,Liu, Xi,Zhao, Xing-Yu,Wu, Fu-An,Wu, Fu-An.

[15]Cooperative Reinforcement of Ionic Liquid and Reactive Solvent on Enzymatic Synthesis of Caffeic Acid Phenethyl Ester as an In Vitro Inhibitor of Plant Pathogenic Bacteria. Xu, Yan,Sheng, Sheng,Liu, Xi,Wang, Chao,Xiao, Wei,Wang, Jun,Wu, Fu-An,Xu, Yan,Sheng, Sheng,Wang, Jun,Wu, Fu-An.

[16]Enhancement of the selective enzymatic biotransformation of rutin to isoquercitrin using an ionic liquid as a co-solvent. Wang, Jun,Sun, Guo-Xia,Wu, Fu-An,Guo, Xi-Jie,Yu, Liang,Wu, Fu-An,Guo, Xi-Jie,Yu, Liang.

[17]Enhancement of Lipase-catalyzed Synthesis of Caffeic Acid Phenethyl Ester in Ionic Liquid with DMSO Co-solvent. Gu, Shuangshuang,Wang, Jun,Wei, Xianbin,Cui, Hongsheng,Wu, Xiangyang,Wu, Fuan,Wang, Jun,Wang, Jun,Wu, Fuan. 2014

[18]Lipase-catalyzed Synthesis of Caffeic Acid Phenethyl Ester in Ionic Liquids: Effect of Specific Ions and Reaction Parameters. Wang Jun,Li Jing,Zhang Leixia,Gu Shuangshuang,Wu Fuan,Wu Fuan. 2013

[19]Ultrasound irradiation accelerates the lipase-catalyzed synthesis of methyl caffeate in an ionic liquid. Wang, Jun,Wang, Shasha,Li, Zhongjian,Gu, Shuangshuang,Wu, Fuan,Wang, Jun,Wang, Shasha,Li, Zhongjian,Gu, Shuangshuang,Wu, Fuan,Wang, Jun,Wu, Xiangyang.

[20]From microalgae oil to produce novel structured triacylglycerols enriched with unsaturated fatty acids. Wang, Jun,Wang, Xu-Dong,Zhao, Xing-Yu,Liu, Xi,Wu, Fu-An,Wang, Jun,Wu, Fu-An,Dong, Tao.

作者其他论文 更多>>

微信小程序