Novel chimeric foot-and-mouth disease virus-like particles harboring serotype O VP1 protect guinea pigs against challenge

文献类型: 外文期刊

第一作者: Li, Haitao

作者: Li, Haitao;Li, Zhiyong;Xie, Yinli;Qin, Xiaodong;Qi, Xingcai;Sun, Peng;Bai, Xingwen;Zhang, Zhidong;Li, Haitao;Ma, Youji

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关键词: FMDV;Virus-like particles;Serotype O;Chimeric VLP

期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )

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收录情况: SCI

摘要: Foot-and-mouth disease is a highly contagious, acute viral disease of cloven-hoofed animal species causing severe economic losses worldwide. Among the seven serotypes of foot-and-mouth disease virus (FMDV), serotype O is predominant, but its viral capsid is more acid sensitive than other serotypes, making it more difficult to produce empty serotype O VLPs in the low pH insect hemolymph. Therefore, a novel chimeric virus-like particle (VLP)-based candidate vaccine for serotype O FMDV was developed and characterized in the present study. The chimeric VLPs were composed of antigenic VP1 from serotype O and segments of viral capsid proteins from serotype Asial. These VLPs elicited significantly higher FMDV-specific antibody levels in immunized mice than did the inactivated vaccine. Furthermore, the chimeric VLPs protected guinea pigs from FMDV challenge with an efficacy similar to that of the inactivated vaccine. These results suggest that chimeric VLPs have the potential for use in vaccines against serotype O FMDV infection. (C) 2015 Elsevier B.V. All rights reserved.

分类号: S8

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