The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques

文献类型： 外文期刊

第一作者： Jin, Ya-Bin

作者： Jin, Ya-Bin;Deng, Qing;Liu, Bei-Lei;Zhuo, Min;Ling, Fei;Liu, Feng-Liang;Zheng, Yong-Tang;liu, Xiao-Hui

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关键词： TRIM5 alpha polymorphism;HIV-2ROD;SIVmac239;Chinese-origin rhesus macaques;Vietnamese-origin cynomolgus macaques

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

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收录情况： SCI

摘要： Because of the difficulty of obtaining Indian-origin rhesus macaques, Chinese-origin rhesus macaques (CR) and Vietnamese-origin cynomolgus macaques (CM) are now used frequently in HIV/AIDS research. Nonetheless, the effects of TRIM5 alpha polymorphism on viral replication in both CR and CM are unclear. To address these questions, we recruited 70 unrelated CR and 40 unrelated CM and studied the effect of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs. We found that 3 polymorphisms, located in the B30.2 domain of CR TRIM5 alpha formed a haplotype and affected HIV-2ROD replication. In addition, we found that the variant Y178H, located in the Coiled-coil domain of CM TRIM5 alpha, affected TRIM5 alpha-mediated HIV-2ROD restriction. Finally, two polymorphisms, located in the Coiled-coil domain, altered anti-SIVmac239 activity in CR. We concluded that, CM TRIM5 alpha polymorphism could alter HIV-2ROD infection; however, a different domain of CR TRIM5 alpha was responsible for restricting different virus replication. (C) 2015 Elsevier Inc. All rights reserved.

分类号： R37

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