Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L.

文献类型： 外文期刊

第一作者： He, Xiao-Feng

作者： He, Xiao-Feng;Hou, Xiao-Dong;Du, Yong-Mei;Zhang, Zhong-Feng;He, Xiao-Feng;Ren, Xia;Guo, Kai;Li, Xiu-Zhuang;Yan, Zhi-Qiang;Qin, Bo;He, Xiao-Feng;Ren, Xia;Guo, Kai;Li, Xiu-Zhuang;Yan, Zhi-Qiang;Qin, Bo

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关键词： N. tabacum;Cembranic diterpenoids;Anti-tumor activities

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

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收录情况： SCI

摘要： Two new cembranoids, together with fifteen known ones, were isolated from the flowers of Nicotiana tabacum L. The structures of the new compounds were established as (1 beta H,2E,4 alpha OH,6 alpha OH,7E,10 alpha H,11 alpha H,12 beta OH)-10,11-epoxy-2,7-cembradiene-4,6,12-triol (1) and (1 beta H,2E,4 alpha OH,6 alpha OH,7E,10 beta H,11 beta H,12 alpha OH)-10,11-epoxy-2,7-cembradiene-4,6, 12-triol (2) by using spectroscopic analysis, including HRESIMS, IR, one-and two-dimensional NMR. A plausible biogenetic relationship of the isolated cembranoids was proposed. The antitumor activities of selected compounds against a panel of three human cancer HepG2, A549 and HCT-116 cell lines were evaluated by the MTT assay. Compound 5 exhibited moderate activity against Hep-G2 cell lines with an IC50 value of 14.38 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

分类号： Q946

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