SMAD7, an antagonist of TGF-beta signaling, is a candidate of prenatal skeletal muscle development and weaning weight in pigs

文献类型： 外文期刊

第一作者： Hua, Chaoju

作者： Hua, Chaoju;Wang, Zishuai;Peng, Xing;Hou, Xinhua;Yang, Yalan;Li, Kui;Tang, Zhonglin;Li, Kui;Tang, Zhonglin;Zhang, Jianbing

作者机构：

关键词： SMAD7;Skeletal muscle development;miRNA-21;Association analysis;Pig

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： SMAD7 promotes and enhances skeletal muscle differentiation by inhibiting transforming growth factor beta (TGF-beta)/activin signaling and bone morphogenetic protein (BMP) pathways. However, its function, the mechanism regulating its translation, and its association with production meat traits remain unclear in pigs. In this study, we explored SMAD7 gene spatio-temporal and tissue distribution, conducted a single nucleotide polymorphism association analysis, and examined regulation of its expression during skeletal muscle development. We found that SMAD7 was positively related to TGF-beta pathway genes and mainly expressed in prenatal developing muscle, and dual luciferase and western blot assays demonstrated that SMAD7 expression was regulated by miRNA-21 at the protein level via inhibition of mRNA translation. Finally, the association analysis showed that a single nucleotide mutation (Exon 4_28816;C/A) was significantly associated with the weaning weight of piglets among Yorkshire pigs. These data indicate that SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.

分类号： Q7

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