Lactobacillus plantarum NCU116 fermented carrot juice evokes changes of metabolites in serum from type 2 diabetic rats

文献类型： 外文期刊

第一作者： Li, Chuan

作者： Li, Chuan;Nie, Shao-Ping;Zhu, Ke-Xue;Xiong, Tao;Xie, Ming-Yong;Li, Chuan;Zhu, Ke-Xue

作者机构：

关键词： Lactobacillus plantarum NCU116;Metabolomics;Biomarkers;Type 2 diabetes;Pathway

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

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收录情况： SCI

摘要： In this study, a novel metabolomics method based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry was developed to investigate the effect of Lactobacillus plantarum NCU116 (NCU116) fermented carrot juice on the metabolites of serum from high fat diet and streptozotocin-induced type 2 diabetic rats. Eight potential biomarkers (adenosine, proline, 5-hydroxyindoleacetaldehyde, glycocholic acid, taurochenodeoxycholic acid, sphingosine, theophylline and taurocholic acid) were identified by unpaired t test analysis, and the pathway features were analyzed by Mass Profiler Professional software. Clustering of partial least squares-discriminant analysis showed that biological pathways and processes, including metabolism of lipids, lipoproteins, purine, tryptophan, bile secretion, fatty acid biosynthesis, glycolysis and gluconeogenesis, were affected by NCU116 fermented carrot juice. These results suggest that metabolomics approach is very useful for studying the mechanisms of action of NCU116 supplement on type 2 diabetes. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： TS2

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