Characterization of surface antigen protein 1 (SurA1) from Acinetobacter baumannii and its role in virulence and fitness

文献类型： 外文期刊

第一作者： Liu, Dong

作者： Liu, Dong;Liu, Zeng-Shan;Hu, Pan;Li, Yan-Song;Lu, Shi-Ying;Liu, Nan-Nan;Ma, Xiao-Long;Chi, Dan;Chang, Jiang;Shui, Yi-Ming;Li, Zhao-Hui;Ahmad, Waqas;Zhou, Yu;Ren, Hong-Lin;Fu, Bao-Quan;Cai, Ling

作者机构：

关键词： Acinetobacter baumannii;Surface antigen protein 1;Gene replacement;Galleria mellonella;Virulence;Fitness

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Acinetobacter baumannii is a Gram-negative bacillus that causes nosocomial infections, such as bacteremia, pneumonia, and meningitis and urinary tract and wound infections. In the present study, the surface antigen protein 1 (SurA1) gene of A. baumannii strain CCGGD201101 was identified, cloned and expressed, and then its roles in fitness and virulence were investigated. Virulence was observed in the human lung cancer cell lines A549 and HEp-2 at one week after treatment with recombinant SurA1. One isogenic SurA1 knock-out strain, GR0015, which was derived from the A. baumannii strain CCGGD201101 isolated from diseased chicks in a previous study, highlighted the effect of SurAl on fitness and growth. Its growth rate in LB broth and killing activity in human sera were significantly decreased compared with strain CCGGD201101. In the Galleria mellonella insect model, the isogenic SurAl knock-out strain exhibited a lower survival rate and decreased dissemination. These results suggest that SurAl plays an important role in the fitness and virulence of A. baumannii. (C) 2016 Elsevier B.V. All rights reserved.

分类号： S8

  • 相关文献

[1]Baseline sensitivity of natural population and resistance risk of Peronophythora litchii to four novel QoI fungicides. Zhou, Yuxin,Liu, Pengfei,Zhang, Yu,Meng, Qingxiao,Liu, Xili,Zhou, Yuxin,Chen, Lei,Hu, Jian,Li, Bin,Si, Naiguo,Liu, Changling.

[2]Efficient gene replacements in ku70 disruption strain of Aspergillus chevalieri var. intermedius. Huang, Qingqing,Huang, Qingqing,Cao, Yang,Liu, Zuoyi,Tan, Yumei,Liu, Yongxiang. 2017

[3]Imazamox microbial degradation by common clinical bacteria: Acinetobacter baumannii IB5 isolated from black soil in China shows high potency. Liu Chun-guang,Yang Xin,Lai Yang,Lu Hong-gang,Zeng Wei-min,Yang Feng-shan,Liu Chun-guang,Zeng Wei-min,Yang Feng-shan,Liu Chun-guang,Geng Gui,Geng Gui. 2016

[4]Characterization of a highly virulent and antimicrobial-resistant Acinetobacter baumannii strain isolated from diseased chicks in China. Liu, Dong,Liu, Zeng-Shan,Hu, Pan,Hui, Qi,Lu, Shi-Ying,Li, Yan-Song,Zou, De-Ying,Li, Zhao-Hui,Yan, Dong-Ming,Ding, Yan-Xia,Zhang, Yuan-Yuan,Zhou, Yu,Liu, Nan-Nan,Ren, Hong-Lin,Fu, Bao-Quan,Zou, De-Ying.

[5]An insecticidal protein from Xenorhabdus ehlersii stimulates the innate immune response in Galleria mellonella. Zeng, HongMei,Yang, XiuFen,Liu, Zheng,Qiu, Dewen. 2013

[6]Identification and characterization of an insect toxin protein, Bb70p, from the entomopathogenic fungus, Beauveria bassiana, using Galleria mellonella as a model system. Khan, Sehroon,Xu, Jianchu,Khan, Sehroon,Xu, Jianchu,Khan, Sehroon,Guo Lihua,Qiu Dewen,Nadir, Sadia,Nadir, Sadia,Holmes, Keith A..

[7]Effect of chlorpyrifos on infectivity and survival of Steinernema feltiae. Chen, SL,Han, XY,Moens, M. 2003

[8]An insecticidal protein from Xenorhabdus budapestensis that results in prophenoloxidase activation in the wax moth, Galleria mellonella. Zeng, Hong-Mei,Yang, Xiu-Fen,Liu, Zheng,Guo, Li-Hua,Yuan, Jing-Jing,Qiu, De-Wen,Yang, Jun,Lin, Hua-Feng,Yang, Jun,Zeng, Hong-Mei,Yang, Xiu-Fen,Liu, Zheng,Guo, Li-Hua,Yuan, Jing-Jing,Qiu, De-Wen. 2012

[9]Ambient insect pressure and recipient genotypes determine fecundity of transgenic crop-weed rice hybrid progeny: Implications for environmental biosafety assessment. Xia, Hui,Zhang, Hongbin,Wang, Wei,Yang, Xiao,Xia, Hanbing,Xu, Kai,Cai, Xingxing,Lu, Bao-Rong,Xia, Hui,Wang, Feng,Su, Jun. 2016

[10]Fitness Advantage of mcr-1-Bearing IncI2 and IncX4 Plasmids in Vitro. Wu, Renjie,Yi, Ling-xian,Yu, Lin-feng,Wang, Jing,Liu, Yiyun,Chen, Xiaojie,Lv, Luchao,Yang, Jun,Liu, Jian-Hua,Chen, Xiaojie. 2018

[11]Analysis of Fitness Predominance for Gaoyou Duck's Double Yolk Egg. Zhang, Tangjie,Chang, Hong,Li, Hui-Fang,Chen, Kuanwei,Zhao, Yonggao,Xuec, Minkai,Zhang, Shengfu. 2011

[12]Effects of SRBSDV-infected rice plants on the fitness of vector and non-vector rice planthoppers. Xu, Hong-Xing,Zheng, Xu-Song,Yang, Ya-Jun,Zhang, Jue-feng,Lu, Zhong-Xian,He, Xiao-Chan. 2016

[13]Effects of insect-resistance transgenes on fecundity in rice (Oryza sativa, Poaceae): A test for underlying costs. Chen, LY,Snow, AA,Wang, F,Lu, BR. 2006

[14]A novel 5-enolpyruvoylshikimate-3-phosphate (EPSP) synthase transgene for glyphosate resistance stimulates growth and fecundity in weedy rice (Oryza sativa) without herbicide. Wang, Wei,Xia, Hui,Yang, Xiao,Xu, Ting,Si, Hong Jiang,Cai, Xing Xing,Lu, Bao-Rong,Wang, Feng,Su, Jun,Snow, Allison A.. 2014

[15]Tomato spotted wilt virus infection reduces the fitness of a nonvector herbivore on pepper. Pan, Huipeng,Chen, Gong,Li, Fei,Wu, Qingjun,Wang, Shaoli,Xie, Wen,Liu, Baiming,Xu, Baoyun,Zhang, Youjun,Chen, Gong.

[16]Enhanced yield performance of Bt rice under target-insect attacks: implications for field insect management. Xia, Hui,Lu, Bao-Rong,Xu, Kai,Wang, Wei,Yang, Xiao,Yang, Chao,Ye, Wenli,Luo, Ju,Lai, Fengxiang,Fu, Qiang.

[17]Sexual selection drives the evolution of limb regeneration in Harmonia axyridis (Coleoptera: Coccinellidae). Wang, S.,Tan, X. L.,Shi, Z. K.,Zhang, F.,Michaud, J. P..

[18]Development and relative fitness of Cry1C resistance in Chilo suppressalis. Chen, Geng,Han, Lanzhi,Peng, Yufang,Tang, Hui,Chen, Fajun. 2018

[19]A fitness cost for Turnip mosaic virus to overcome host resistance. Jenner, CE,Wang, XW,Ponz, F,Walsh, JA. 2002

[20]Changes of inheritance mode and fitness in Helicoverpa armigera (Hubner) (Lepidoptera : Noctuidae) along,with its resistance evolution to Cry1Ac toxin. Wu, Kong-Ming,Yu, Hong-Kun,Li, Ke-Ke,Feng, Xue,Guo, Yu-Yuan. 2008

作者其他论文 更多>>

微信小程序