Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons
文献类型： 外文期刊
第一作者： Bai, Jing
作者： Bai, Jing;Zhang, Wei;Chen, Ming;Lin, Min;Xu, Yuquan;Bai, Jing;Lu, Yuanyuan;Xu, Ya-ming;Gunatilaka, A. A. Leslie;Molnar, Istvan;Lu, Yuanyuan
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期刊名称：ORGANIC LETTERS （ 影响因子：6.005； 五年影响因子：5.551 ）
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收录情况： SCI
摘要： Two disparate polyketide families, the benzenediol lactones and the azaphilones, are produced by fungi using iterative polyketide synthase (iPKS) enzymes consisting of collaborating partner subunits. Exploitation of this common biosynthetic logic using iPKS subunit shuffling allowed the diversity-oriented combinatorial biosynthesis of unprecedented polyketide scaffolds new to nature, bearing structural motifs from both of these orthogonal natural product families. Starter unit acyltransferase domain replacements proved necessary but not sufficient to guarantee communication between iPKS subunits.
分类号： O62
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