Preparation of nanoliposome loaded with peanut peptide fraction: stability and bioavailability

文献类型： 外文期刊

第一作者： Gong, Kui-Jie

作者： Gong, Kui-Jie;Shi, Ai-Min;Liu, Hong-Zhi;Liu, Li;Hu, Hui;Yang, Ying;Wang, Qiang;Gong, Kui-Jie;Adhikari, Benu

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期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）

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收录情况： SCI

摘要： Nanoliposome loaded with peanut peptide fraction (PPF) prepared by high pressure microfluidization (HPM) treatment was investigated as well as its stability and bioavailability. PPF showed hydrophilicity character with a solubility of 97.50 +/- 2.31 mg mL(-1) in aqueous solution. HPM treatment can prepare nanoliposome but decreased encapsulation efficiency (EE). A pressure of 120 MPa was the appropriate parameter where the particle size and EE of nanolipsome was 79.67 +/- 1.85 nm and 65.12 +/- 2.96%, respectively. Crude liposome and nanoliposome both showed good stability under different pH conditions, even at pH value of 2.0. Nanoliposome behaved better in vitro controlled release than crude liposome. Most important of all, nanoliposome had the highest angiotension converting enzyme (ACE) inhibitory activity after simulated gastrointestinal tract (GIT) digestion. Morphology of digested liposome proved that nanoliposome can keep relative integrity in structure although it suffered a lot of attack.

分类号： TS2

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