Effect of drying and loading methods on the release behavior of ciprofloxacin from starch nanoparticles

文献类型： 外文期刊

第一作者： Shi, Aimin

作者： Shi, Aimin;Liu, Hongzhi;Wang, Qiang;Shi, Aimin;Li, Dong;Adhikari, Benu

作者机构：

关键词： Starch nanoparticles;Biological macromolecule;Controlled release kinetics;Ciprofloxacin;Coating;Adsorption

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Drug loading into and release from starch nanoparticles (StNPs), one kind of novel biological macromolecule, were investigated. Two drying methods (spray and vacuum freeze drying) and drug loading methods (coating and adsorption) were used for evaluation. 40% (w/w) of ciprofloxacin was loaded using coating method while only 7% for adsorption method. Glass transition temperature (T-g) and melting point temperature (T-mp) of ciprofloxacin loaded starch nanoparticles varied from 40 degrees C to 55 degrees C and 125 degrees C to 175 degrees C. Particles using adsorption method had lower loading rate of ciprofloxacin, higher T-g, Tmp and release rate compared to using coating method. Tg and Tmp were not affected by these two drying methods. Release rate of ciprofloxacin was higher from freeze dried particles than from spray dried particles using coating method. For adsorption method, drying methods had not effect on the release rate. A double decay exponential model was able to fit the release data suitably well with coefficient of determination (R-2)>0.97. (C) 2016 Elsevier B.V. All rights reserved.

分类号： Q71

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