Recombinant Newcastle disease virus expressing H9 HA protects chickens against heterologous avian influenza H9N2 virus challenge

文献类型: 外文期刊

第一作者: Nagy, Abdou

作者: Nagy, Abdou;Lee, Jinhwa;Henningson, Jamie;Li, Yuhao;Ma, Jingjiao;Duff, Michael;Li, Yonghai;Lang, Yuekun;Yang, Jianmei;Richt, Juergen;Ma, Wenjun;Nagy, Abdou;Abdallah, Fatma;Ali, Ahmed;Mena, Ignacio;Garcia-Sastre, Adolfo;Mena, Ignacio;Garcia-Sastre, Adolfo;Yang, Jianmei;Garcia-Sastre, Adolfo

作者机构:

关键词: Influenza;Recombinant NDV LaSota viruses;H9N2;Cross-protection

期刊名称:VACCINE ( 影响因子:3.641; 五年影响因子:3.816 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: In order to produce an efficient poultry H9 avian influenza vaccine that provides cross-protection against multiple H9 lineages, two Newcastle disease virus (NDV) LaSota vaccine strain recombinant viruses were generated using reverse genetics. The recombinant NDV-H9Con virus expresses a consensus-H9 hemagglutinin (HA) that is designed based on available H9N2 sequences from Chinese and Middle Eastern isolates. The recombinant NDV-H9Chi virus expresses a chimeric-H9 HA in which the H9 ectodomain of A/Guinea Fowl/Hong Kong/WF10/99 was fused with the cytoplasmic and transmembrane domain of the fusion protein (F) of NDV. Both recombinant viruses expressed the inserted HA stably and grew to high titers. An efficacy study in chickens showed that both recombinant viruses were able to provide protection against challenge with a heterologous H9N2 virus. In contrast to the NDV-H9Chi virus, the NDV-H9Con virus induced a higher hemagglutination inhibition titer against both NDV and H9 viruses in immunized birds, and efficiently inhibited virus shedding through the respiratory route. Moreover, sera collected from birds immunized with either NDV-H9Con or NDV-H9Chi were able to cross-neutralize two different lineages of H9N2 viruses, indicating that NDV-H9Con and NDV-H9Chi are promising vaccine candidates that could provide cross-protection among different H9N2 lineage viruses. (C) 2016 Elsevier Ltd. All rights reserved.

分类号: R392

  • 相关文献

[1]Assessment of antibiotic susceptibilities, genotypic characteristics and biofilm-forming abilities of Staphylococcus aureus and Salmonella Typhimurium. Xu, Hua,Ahn, Juhee,Xu, Hua,He, Xinlong,Ahn, Juhee. 2011

[2]A Streptococcus iniae DNA vaccine delivered by a live attenuated Edwardsiella tarda via natural infection induces cross-genus protection. Sun, Y.,Hu, Y-H.,Sun, L.,Sun, Y.,Liu, C-S.. 2012

[3]A effective DNA vaccine against diverse genotype J infectious hematopoietic necrosis virus strains prevalent in China. Xu, Liming,Zhao, Jingzhuang,Liu, Miao,Ren, Guangming,Yin, Jiasheng,Liu, Hongbai,Lu, Tongyan,Kurath, Gael,Lapatra, Scott E.,Feng, Jian.

[4]Primary Babesia rodhaini infection followed by recovery confers protective immunity against B. rodhaini reinfection and Babesia microti challenge infection in mice. Wang, Guanbo,Efstratiou, Artemis,Moumouni, Paul Franck Adjou,Liu, Mingming,Jirapattharasate, Charoonluk,Guo, Huanping,Gao, Yang,Suzuki, Hiroshi,Igarashi, Ikuo,Xuan, Xuenan,Cao, Shinuo,Zhou, Mo.

[5]Cross-Glade protective immune responses of NS1-truncated live attenuated H5N1 avian influenza vaccines. Shi, Shaohua,Chen, Sujuan,Han, Weizhou,Wu, Bai,Zhang, Xiaojian,Tang, Ying,Wang, Xiao,Zhu, Yinbiao,Peng, Daxin,Liu, Xiufan,Shi, Shaohua,Chen, Sujuan,Han, Weizhou,Wu, Bai,Zhang, Xiaojian,Tang, Ying,Wang, Xiao,Zhu, Yinbiao,Peng, Daxin,Liu, Xiufan,Shi, Shaohua,Chen, Sujuan,Han, Weizhou,Wu, Bai,Zhang, Xiaojian,Tang, Ying,Wang, Xiao,Zhu, Yinbiao,Peng, Daxin,Liu, Xiufan,Shi, Shaohua.

[6]Evaluation of cross-protection against three topotypes of serotype O foot-and-mouth disease virus in pigs vaccinated with multi-epitope protein vaccine incorporated with poly(I:C). Cao, Yimei,Lu, Zengjun,Li, Dong,Fan, Pengju,Sun, Pu,Bao, Huifang,Fu, Yuanfang,Li, Pinghua,Bai, Xingwen,Chen, Yingli,Xie, Baoxia,Liu, Zaixin.

[7]Characterization and cross-protection evaluation of M949_1603 gene deletion Riemerella anatipestifer mutant RA-M1. Zou, Jiechi,Wang, Xiaolan,Ding, Chan,Tian, Mingxing,Han, Xiangan,Wang, Shaohui,Yu, Shengqing.

[8]Molecular and antigenic characterization of bovine Coronavirus circulating in Argentinean cattle during 1994-2010. Bok, M.,Mino, S.,Rodriguez, D.,Badaracco, A.,Vega, C.,Parreno, V.,Mino, S.,Nunes, I.,Souza, S. P.,Bilbao, G.,Odeon, A.,Louge Uriarte, E.,Galarza, R.,Saif, L. J..

[9]Diversified reassortant H9N2 avian influenza viruses in chicken flocks in northern and eastern China. Huang, Yanyan,Hu, Beixia,Zhang, Xiumei,Huang, Yanyan,Wen, Xintian,Cao, Sanjie,Du, Qijing,Gavrilov, Boris K.,Khan, Mazhar I.. 2010

[10]Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice. Bi, Yuhai,Lu, Lu,Li, Jing,Zeshan, Basit,Sun, Lei,Liu, Wenjun,Lu, Lu,Yin, Yanbo,Qin, Zhuoming,Zhang, Yi,Gao, Huijie,Liu, Jinhua. 2011

[11]Evolution of H9N2 influenza viruses from domestic poultry in Mainland China. Li, CJ,Yu, KZ,Tian, GB,Yu, DD,Liu, LL,Jing, B,Ping, JH,Chen, HL.

[12]Lowly pathogenic avian influenza (H9N2) infection in Plateau pika (Ochotona curzoniae), Qinghai Lake, China. Yu, Zhijun,Zhang, Kun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Zhang, Kun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Cheng, Kaihui,Sun, Weiyang,Xin, Yue,Li, Lin,Huang, Jing,Sang, Xiaoyu,Li, Xue,Wang, Tiecheng,Qian, Jun,Gao, Yuwei,Xia, Xianzhu,Cai, Jinshan,Ma, Ruilin,Zhao, Quanbang,Cheng, Kaihui,Huang, Jing,Li, Xue.

[13]Generation and application of replication-competent Venus-expressing H5N1, H7N9, and H9N2 influenza A viruses. Wang, Guangwen,Zhang, Jie,Kong, Fandi,Li, Qibing,Wang, Jinliang,Ma, Shujie,Zhao, Yuhui,Liang, Libin,Li, Junping,Sun, Nan,Guan, Lizheng,Zhou, Yuan,Zhou, Chenchen,Huang, Shanyu,Bu, Zhigao,Jiang, Li,Chen, Hualan,Li, Chengjun. 2018

[14]Influenza virus-like particles harboring H9N2 HA and NA proteins induce a protective immune response in chicken. Li, Xin,Ju, Houbin,Liu, Jian,Yang, Dequan,Qi, Xinyong,Yang, Xianchao,Ge, Feifei,Zhou, Jinping,Qiu, Yafeng,Zheng, Jie. 2017

[15]Phylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds:High Homology of Internal Genes with Human H10N8 Virus. Ye, Ge,Liang, Chai Hong,Ping, Hua Yu,Hua, Deng Guo,Lan, Chen Hua,Song, Lei Yong,Xiang, Yang Guo,Guang, Chen. 2016

[16]Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections. Cheng, Yuqiang,Huang, Qingqing,Ji, Wenhui,Du, Bin,Fu, Qiang,An, Huiting,Wang, Hengan,Yan, Yaxian,Ding, Chan,Sun, Jianhe,Ding, Chan,Li, Jing.

[17]N-glycan profiles in H9N2 avian influenza viruses from chicken eggs and human embryonic lung fibroblast cells. Chen, Wentian,Zhong, Yaogang,Su, Rui,Qi, Huicai,Deng, Weina,Sun, Yu,Ma, Tianran,Wang, Xilong,Yu, Hanjie,Li, Zheng,Wang, Xiurong.

[18]Two Genetically Similar H9N2 Influenza A Viruses Show Different Pathogenicity in Mice. Liu, Qingtao,Liu, Yuzhuo,Yang, Jing,Huang, Xinmei,Han, Kaikai,Zhao, Dongmin,Bi, Keran,Li, Yin,Liu, Qingtao,Liu, Yuzhuo,Yang, Jing,Huang, Xinmei,Han, Kaikai,Zhao, Dongmin,Bi, Keran,Li, Yin. 2016

[19]Characterization of influenza A virus with nine segments: Effect gene segment on virus property. Wu, Rui,Shao, Huabin,Luo, Qingping,Yang, Jun,Xu, Diping,Wu, Rui,Shao, Huabin,Xu, Diping,Wu, Rui,Zhang, Xuke. 2012

[20]Comparative analysis of selected innate immune-related genes following infection of immortal DF-1 cells with highly pathogenic (H5N1) and low pathogenic (H9N2) avian influenza viruses. Liu, Ai-ling,Pan, Jie,Li, Yu-feng,Ma, Xiu-Li,Yu, Ke-xiang,Huang, Bing,Song, Min-xun,Qi, Wenbao,Liao, Ming,Li, Feng,Li, Feng.

作者其他论文 更多>>