The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-beta signaling pathway

文献类型： 外文期刊

第一作者： Li, Dan

作者： Li, Dan;Yang, Wenping;Yang, Fan;Liu, Huanan;Zhu, Zixiang;Lian, Kaiqi;Liu, Xiangtao;Zheng, Haixue;Lei, Caoqi;Li, Shu;Shu, Hongbing

作者机构：

关键词： Aphthovirus;innate immunity;pathogen

期刊名称：FASEB JOURNAL （ 影响因子：5.191； 五年影响因子：5.955 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Foot-and-mouth disease is a frequently occurring disease of cloven-hoofed animals that is caused by infection with the foot-and-mouth virus (FMDV). FMDV circumvents the type-I IFN response by expressing proteins that antagonize cellular innate immunity, such as leader protease and 3C protease. We identified the FMDV structural protein VP3 as a negative regulator of the virus-triggered IFN-beta signaling pathway. Expression of FMDV VP3 inhibited the Sendai virus-triggered activation of IFN regulatory factor-3 and the expression of retinoic acid-inducible gene-I/melanoma differentiation-associated protein-5. Transient transfection and coimmunoprecipitation confirmed that the structural protein VP3 interacts with virus-induced signaling adapter (VISA), which is dependent on the C-terminal aa 111-220 of VP3. In addition, we found that FMDV VP3 inhibits the expression of VISA by disrupting its mRNA. Taken together, our findings reveal a novel strategy used by the structural VP3 protein of FMDV to evade host innate immunity.-Li, D., Yang, W., Yang, F., Liu, H., Zhu, Z., Lian, K., Lei, C., Li, S., Liu, X., Zheng, H., Shu, H. The VP3 structural protein of foot-andmouth disease virus inhibits the IFN-beta signaling pathway.

分类号： Q5

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