Relationship of long noncoding RNA and viruses

文献类型： 外文期刊

第一作者： Zhang, Jie

作者： Zhang, Jie;Zhang, Yong-Guang

作者机构：

关键词： Long noncoding RNA;Epstein-Barr virus;Theiler's virus;Adenovirus;Cytomegalovirus

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

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收录情况： SCI

摘要： Long noncoding (lnc) RNAs comprise a diverse group of transcripts including large intervening noncoding (linc) RNAs, natural antisense transcripts (NATs) and intronic lncRNAs. The functions and mechanisms of more than 200 lncRNAs have been studied in vitro and the results suggest that lncRNAs may be molecular markers of prognosis in cancer patients. Some lncRNAs can promote virus replication and allowescape from cytosolic surveillance to suppress antiviral immunity. For example, lncRNA can cause persistent infection by Theiler's virus, and microRNA (miR)-27a/b is important for efficientmurine cytomegalovirus (MCMV) replication. The available evidence suggests that lncRNAs may be potential targets of novel antiviral drugs. (C) 2016 The Authors. Published by Elsevier Inc.

分类号： R394

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