Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer

文献类型： 外文期刊

第一作者： Duan, Liangwei

作者： Duan, Liangwei;Du, Jiansen;Liu, Xinqi;Wang, Xuefeng;Zhou, Jianhua;Wang, Xiaojun

作者机构：

关键词： EIAV gp45;HIV-1 gp41;Crystal structure;FPPR;Asparagine/Glutamine-rich layer;Membrane fusion;Conformational transition

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN：

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收录情况： SCI

摘要： Equine infectious anaemia virus (EIAV) and human immunodeficiency virus (HIV) are members of the lentiviral genus. Similar to HIV gp41, EIAV gp45 is a fusogenic protein that mediates fusion between the viral particle and the host cell membrane. The crystal structure of gp45 reported reveals a different conformation in the here that includes the fusion peptide proximal region (FPPR) and neighboring asparagine-rich layer compared with previous HIV-1 gp41 structures. A complicated hydrogen-bond network containing a cluster of solvent molecules appears to be critical for the stability of the gp45 helical bundle. Interestingly, viral replication was relatively unaffected by site-directed mutagenesis of EIAV, in striking contrast to that of HIV-1. Based on these observations, we speculate that EIAV is more adaptable to emergent mutations, which might be important for the evolution of EIAV as a quasi-species, and could potentially contribute to the success of the EIAV vaccine. (C) 2016 Elsevier Inc. All rights reserved.

分类号： R37

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