Effect of Increasing Doses of Linoleic and alpha-Linolenic Acids on High-Fructose and High-Fat Diet Induced Metabolic Syndrome in Rats

文献类型： 外文期刊

第一作者： Zhang, Jianan

作者： Zhang, Jianan;Wang, Ou;Guo, Yingjian;Wang, Siyi;Li, Guopeng;Ji, Baoping;Wang, Tuo;Ji, Baoping;Deng, Qianchun;Deng, Qianchun

作者机构：

关键词： linoleic acid;alpha-linolenic acid;dose;ratio;metabolic syndrome

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Doses and ratio of linoleic acid (LA) and a-linolenic acid (ALA) preventing metabolic syndrome (MS) were investigated. SD rats were fed (i) basal diet, (ii) high -fructose and high-fat diet (HFFD), (iii) HFFD with increasing-dose LA (0.75 energy-% ALA + 3, 6, 9, 12, 15, and 30 energy-% LA), and (iv) HFFD with increasing-dose ALA (6 energy-% LA + 0.3, 0.5, 0.75, 1.5, 2.25, and 3.75 energy-% ALA) for 18 weeks. Results showed 6, 12, 15, and 30 energy-% LA significantly ameliorated central obesity, hyperlipidemia, glucose homeostasis, and leptin status; 0.5 and 0.75 energy-% ALA significantly improved insulin sensitivity, adiponectin, and anti-inflammatory status. Moreover, high intakes of ALA (1.5, 2.25, and 3.75 energy-%) presented a pro-oxidant activity. In conclusion, dose instead of ratio determines the prevention of MS. The optimal doses are 6 energy-% LA and 0.75 energy-% ALA; high intakes of ALA may have side effects.

分类号： R15`S

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