New Analytical Tool for the Detection of Ractopamine Abuse in Goat Skeletal Muscle by Potential Gene Expression Biomarkers

文献类型： 外文期刊

第一作者： Zhao, Luyao

作者： Zhao, Luyao;Yang, Shuming;Zhang, Yanhua;Zhang, Ying;Hou, Can;Cheng, Yongyou;You, Xinyong;Tarique, Tunio Muhammad;Gu, Xu;Zhao, Zhen

作者机构：

关键词： biomarkers;gene expression;beta(2)-agonist;goat

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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年卷期：

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收录情况： SCI

摘要： In this study, quantification of mRNA gene expression was examined as biomarkers to detect ractopamaine abuse and ractopamaine residues in cashmere goats. It was focused on the identification of potential gene expression brignarkers and describing the coreletionship between gene expression and residue level by 58 animals for 49 days. The results showed that administration periods and residue levels significantly influenced mRNA expressions of the beta(2)-adrenergic receptor (beta(2)AR), the enzymes PRKACB, ADCY3, ATP1A3, ATP2A3, PTH, and MYLK, and the immune factors IL-1 beta and TNF-alpha. Statistical analysis like principal components analysis (PCA), hierarchical cluster analysis (HCA), and discriminant analysis (DA) showed that these genes can serve as potential biomarkers for ractopamine in skeletal muscle and that they are also suitable for describing different residue levels separately.

分类号： R15`S

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