Antitumor activity of Dendrobium devonianum polysaccharides based on their immunomodulatory effects in S180 tumor-bearing mice

文献类型： 外文期刊

第一作者： Tong, Litao

作者： Tong, Litao;Wang, Lili;Zhou, Xianrong;Zhong, Kui;Liu, Liya;Wang, Fengzhong;Zhou, Sumei

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期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）

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收录情况： SCI

摘要： The aim of the present study is to investigate the antitumor activity and immunostimulatory effect of the water-soluble polysaccharides (DDP) from stem of Dendrobium devonianum in S180 tumor-bearing mice. The mice were divided into 3 groups, and then DDP or Ganoderma lucidum polysaccharides (GLP) dissolved in deionized water were given to the mice at a dose of 200 mg kg(-1) for 30 days. DDP, as well as GLP, significantly inhibited the growth of mouse transplantable tumors and promoted spleen indexes, delayed-type hypersensitivity reaction, natural killer cell activity, macrophage phagocytosis and lymphocyte proliferation. Moreover, DDP and GLP increased the colonic acetate, butyrate and total short-chain fatty acid (SCFA) concentrations. These results indicated that oral administration of DDP significantly inhibited the growth of transplanted tumors in S180 tumor-bearing mice by improving specific and non-specific immune responses, as well as increasing colonic SCFAs.

分类号： O6

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