Short communication: N-Acetylcysteine-mediated modulation of antibiotic susceptibility of bovine mastitis pathogens

文献类型: 外文期刊

第一作者: Yang, F.

作者: Yang, F.;Liu, L. H.;Li, X. P.;Luo, J. Y.;Zhang, Z.;Yan, Z. T.;Zhang, S. D.;Li, H. S.

作者机构:

关键词: N-acetylcysteine;bovine mastitis;pathogen;antibiotic susceptibility

期刊名称:JOURNAL OF DAIRY SCIENCE ( 影响因子:4.034; 五年影响因子:4.354 )

ISSN:

年卷期:

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收录情况: SCI

摘要: The aim of this study was to investigate the effects of N-acetylcysteine (NAC) on antibiotic susceptibility of bovine mastitis pathogens including Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli, and Streptococcus agalactiae. Minimum inhibitory concentrations (MIC) were tested by the agar-based E-test method. The presence of 10 mM NAC reduced the MIC of penicillin and ampicillin but enhanced the MIC of erythromycin and ciprofloxacin for all of the strains. In addition, NAC-mediated modulation of MIC of kanamycin, tetracycline, and vancomycin was diverse, depending on the target bacterial pathogen and antibiotic being used. The results suggest that NAC is an important modulator of antibiotic activity against the major bovine mastitis pathogens.

分类号: TS252

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