Nitric Oxide Inhibitory Meroterpenoids from the Fungus Penicillium purpurogenum MHZ 111

文献类型： 外文期刊

第一作者： Sun, Jing

作者： Sun, Jing;Zhu, Zhi-Xiang;Song, Yue-Lin;Zheng, Jiao;Zhao, Yun-Fang;Tu, Peng-Fei;Li, Jun;Sun, Jing;Dong, Dan;Liu, Ting;Ferreira, Daneel;Zjawiony, Jordan K.;Ferreira, Daneel;Zjawiony, Jordan K.

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期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

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收录情况： SCI

摘要： Five new meroterpenoids, purpurogenolides A E (1-5), and four known metabolites (6-9) were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHz 111. The structures of the new meroterpenoids were elucidated by analysis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of 1 and 5 were determined by single-crystal X-ray crystallographic analysis, and those of 2-4 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compounds 2-4 and 6 showed inhibition of nitric oxide production in lipopolysaccharideactivated BV-2 microglial cells with IC50 values of 0.8-30.0 mu M.

分类号： R93

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