Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus
文献类型： 外文期刊
第一作者： Zhao, Yangyang
作者： Zhao, Yangyang;Qian, Guoliang;Ye, Yonghao;Liu, Fengquan;Zhao, Yangyang;Wright, Stephen;Chen, Haotong;Du, Liangcheng;Shen, Yuemao;Liu, Fengquan
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期刊名称：ORGANIC LETTERS （ 影响因子：6.005； 五年影响因子：5.551 ）
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收录情况： SCI
摘要： Heterocyclic aromatic N-oxides often have potent biological activities, but the mechanism for aromatic N-oxidation is unclear. Six phenazine antibiotics were isolated from Lysobacter antibioticus OH13. A 10 gene cluster was identified for phenazine biosynthesis. Mutation of LaPhzNO1 abolished all N-oxides, while non-oxides markedly increased. LaPhzNO1 is homologous to Baeyer-Villiger flavoproteins but was shown to catazlye phenazine N-oxidation. LaPhzNO1 and LaPhzS together converted phenazine 1,6-dicarboxylic acid to 1,6-dihydroxyphenazine N5,N10-dioxide. LaPhzNO1 also catalyzed N-oxidation of 8-hydroxyquinoline.
分类号： O62
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