Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-gamma signal transduction pathways

文献类型: 外文期刊

第一作者: Li, Dan

作者: Li, Dan;Yang, Fan;Liu, Hua-Nan;Zhu, Zi-Xiang;Cao, Wei-Jun;Liu, Xiang-Tao;Zheng, Hai-Xue;Wei, Jin;Li, Shu;Shu, Hong-Bing

作者机构:

关键词: Foot-and-mouth disease virus;IFN-;signaling pathway;janus kinase 1;structural protein VP3

期刊名称:CELL CYCLE ( 影响因子:4.534; 五年影响因子:4.492 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Foot-and-mouth disease is a highly contagious viral disease of cloven-hoofed animals that is caused by foot-and-mouth disease virus (FMDV). To replicate efficiently in vivo, FMDV has evolved methods to circumvent host antiviral defense mechanisms, including those induced by interferons (IFNs). Previous research has focused on the effect of FMDV L-pro and 3C(pro) on type I IFNs. In this study, FMDV VP3 was found to inhibit type II IFN signaling pathways. The overexpression of FMDV VP3 inhibited the IFN--triggered phosphorylation of STAT1 at Tyr701 and the subsequent expression of downstream genes. Mechanistically, FMDV VP3 interacted with JAK1/2 and inhibited the tyrosine phosphorylation, dimerization and nuclear accumulation of STAT1. FMDV VP3 also disrupted the assembly of the JAK1 complex and degraded JAK1 but not JAK2 via a lysosomal pathway. Taken together, the results reveal a novel mechanism used by which FMDV VP3 counteracts the type II IFN signaling pathways.

分类号: Q2

  • 相关文献

[1]Kobuvirus VP3 protein restricts the IFN-beta-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation. Peng, Qianqian,Lan, Xi,Wang, Chen,Wang, Junyong,Zhu, Qiyun,Ren, Yujie,Yue, Ningning,Zhong, Bo,Zhong, Bo. 2017

[2]Molecular characterization and expression analysis of the I kappa B gene from pearl oyster Pinctada fucata. Xu, Xinping,Zhang, Dianchang,Jiang, Shigui,Qiu, Lihua,Su, Tianfeng,Wu, Kaichang,Li, Youning,Zhu, Caiyan,Zhang, Dianchang. 2009

[3]Molecular characterization and expression analysis of a putative LPS-induced TNF-alpha factor (LITAF) from pearl oyster Pinctada fucata. Zhang, Dianchang,Jiang, Jingjing,Jiang, Shigui,Ma, Jianjun,Su, Tianfeng,Qiu, Lihua,Zhu, Caiyan,Zhang, Dianchang,Jiang, Jingjing,Ma, Jianjun,Xu, Xinping,Xu, Xinping. 2009

[4]Regulation of plant stress response by dehydration responsive element binding (DREB) transcription factors. Zhou, Mei-Liang,Ma, Jiang-Tao,Pang, Jun-Feng,Tang, Yi-Xiong,Wu, Yan-Min,Ma, Jiang-Tao,Pang, Jun-Feng,Zhang, Zhan-Lu,Zhou, Mei-Liang. 2010

[5]Expression of the ethylene response factor gene TSRF1 enhances abscisic acid responses during seedling development in tobacco. Zhang, Hongbo,Zhang, Zhijin,Huang, Rongfeng,Zhang, Hongbo,Chen, Jia,Wang, Xue-Chen,Yang, Yuhong,Zhang, Hongbo,Zhang, Zhijin,Huang, Rongfeng.

[6]The p53-Bak apoptotic signaling axis plays an essential role in regulating differentiation of the ocular lens. Deng, M.,Ji, W.,Zhang, X.,Gong, L.,Hu, X.,Hu, W.,Xiao, L.,Li, D. W. -C.,Chen, P.,Liu, F.,Fu, S.,Tang, H.,Fu, Y.,Xiong, Z.,Hui, S.,Hu, X.,Hu, W.,Xiao, L.,Liu, W. -B.,Xiao, Y. -M.,Liu, S. -J.,Liu, Y.,Li, D. W. -C.,Zhang, L.,Sun, S.,Liu, J.,Li, D. W. -C..

[7]Low-current & high-frequency electrical stunning increased oxidative stress, lipid peroxidation, and gene transcription of the mitogen-activated protein kinase/nuclear factor-erythroid 2-related factor 2/antioxidant responsive element (MAPK/Nrf2/ARE) signaling pathway in breast muscle of broilers. Xu, Lei,Zhang, Hai-jun,Yue, Hong-yuan,Wu, Shu-geng,Qi, Guang-hai,Xu, Lei,Yang, Hai-ming,Wang, Zhi-yue. 2018

[8]D-Glucose and amino acid deficiency inhibits casein synthesis through JAK2/STAT5 and AMPK/mTOR signaling pathways in mammary epithelial cells of dairy cows. Zhang, M. C.,Zhao, S. G.,Wang, S. S.,Luo, C. C.,Gao, H. N.,Zheng, N.,Wang, J. Q.,Zhang, M. C.,Zhao, S. G.,Wang, S. S.,Luo, C. C.,Gao, H. N.,Zheng, N.,Wang, J. Q.,Zhang, M. C.,Zhao, S. G.,Wang, S. S.,Luo, C. C.,Gao, H. N.,Zheng, N.,Wang, J. Q.,Zhang, M. C.,Zhao, S. G.,Wang, S. S.,Luo, C. C.,Gao, H. N.,Zheng, N.,Wang, J. Q.. 2018

[9]Validation of Reference Genes for Quantitative Real-Time PCR in Bovine PBMCs Transformed and Non-transformed by Theileria annulata. Zhao, Hongxi,Liu, Junlong,Li, Youquan,Yang, Congshan,Zhao, Shuaiyang,Liu, Juan,Liu, Aihong,Liu, Guangyuan,Yin, Hong,Guan, Guiquan,Luo, Jianxun,Yin, Hong,Zhao, Hongxi. 2016

[10]The Protein Elicitor PevD1 Enhances Resistance to Pathogens and Promotes Growth in Arabidopsis. Khan, Najeeb Ullah,Wang, Ningbo,Yang, Xiufen,Qiu, Dewen. 2016

[11]Cherry Valley Ducks Mitochondrial Antiviral-Signalling Potein-Mediated Signaling Pathway and Antiviral Acitvity Research. Li, Ning,Hong, Tianqi,Li, Rong,Wang, Yao,Guo, Mengjiao,Cai, Yumei,Liu, Sidang,Chai, Tongjie,Wei, Liangmeng,Li, Ning,Chai, Tongjie,Wei, Liangmeng,Cao, Zongxi. 2016

[12]Differential gene expressions of NLRC5 signaling pathway in chicken macrophages cells response to Salmonella Enteritidis derived lipopplysaccharides stimulation. Qiu, Lingling,Chang, Guobin,Liu, Xiangping,Li, Zhiteng,Lu, Wei,Ren, Lichen,Xu, Lu,Wan, Fang,Guo, Xiaomin,Chen, Guohong,Qiu, Lingling,Chang, Guobin,Li, Zhiteng,Lu, Wei,Ren, Lichen,Xu, Lu,Wan, Fang,Guo, Xiaomin,Chen, Guohong.

[13]The SnRK Protein Kinase Family and the Function of SnRK1 Protein Kinase. Cui Na,Li Tian-Lai,Dong Xue-Fei,Wang Li,Zhao Xiao-Cui,Qu Bo,Zhang Guo-Liang. 2012

[14]Polyclonal antibody to porcine p53 protein: A new tool for studying the p53 pathway in a porcine model. Qiu, Yafeng,Shen, Yang,Li, Xiangdong,Liu, Qingwei,Ma, Zhiyong. 2008

[15]Gbvdr6, a Gene Encoding a Receptor-Like Protein of Cotton (Gossypium barbadense), Confers Resistance to Verticillium Wilt in Arabidopsis and Upland Cotton. Yang, Yuwen,Ma, Zhengqiang,Yang, Yuwen,Ma, Zhengqiang,Yang, Yuwen,Chen, Tianzi,Ling, Xitie. 2018

[16]Characterization and induction kinetics of a putative candidate gene associated with downy mildew resistance in grapevine. Liang, C.,Liu, L.,Zang, C.,Zhao, K.,Liu, C..

[17]Genome-wide analysis and environmental response profiling of the FK506-binding protein gene family in maize (Zea mays L.). Yu, Yanli,Zhang, Hui,Li, Wencai,Mu, Chunhua,Zhang, Fajun,Wang, Liming,Meng, Zhaodong.

[18]Inhibitory action of tongue sole LPXRFa, the piscine ortholog of gonadotropin-inhibitory hormone, on the signaling pathway induced by tongue sole kisspeptin in COS-7 cells transfected with their cognate receptors. Wang, Bin,Liu, Quan,Xu, Yongjiang,Liu, Xuezhou,Shi, Bao,Wang, Bin,Xu, Yongjiang,Liu, Xuezhou,Shi, Bao,Yang, Guokun,Qin, Jingkai,Li, Wensheng,Yang, Guokun,Qin, Jingkai,Li, Wensheng,Liu, Quan.

[19]CpG DNA enhances the immune responses elicited by the DNA vaccine against foot-and-mouth disease virus in guinea pigs. Li, GJ,Li, YJ,Yan, WY,Xu, QX,Wu, YQ,Xie, Y,You, YJ,Zheng, ZX. 2001

[20]Enhanced immunogenicity of multiple-epitopes of foot-and-mouth disease virus fused with porcine interferon alpha in mice and protective efficacy in guinea pigs and swine. Du, Yijun,Li, Yufeng,Jiang, Wenming,Wang, Xinglong,Tang, Bo,Cao, Jun,Wang, Xianwei,Jian, Ping,He, Hairong,Qi, Jing. 2008

作者其他论文 更多>>