Sesquiterpenoids with PTP1B Inhibitory Activity and Cytotoxicity from the Edible Mushroom Pleurotus citrinopileatus

文献类型： 外文期刊

第一作者： Tao, Qiao-Qiao

作者： Tao, Qiao-Qiao;Ma, Ke;Bao, Li;Wang, Kai;Han, Jun-Jie;Wang, Wen-Zhao;Liu, Hong-Wei;Tao, Qiao-Qiao;Zhang, Jin-Xia;Huang, Chen-Yang

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关键词： Pleurotus citrinopileatus;Pleurotaceae;bisabolane sesquiterpene;PTP1B inhibitor

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

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收录情况： SCI

摘要： One new perhydrobenzannulated 5,5-spiroketal sesquiterpene, pleurospiroketal F (1), as well as six new modified bisabolene sesquiterpenes pleurotins A-F (2-7) were isolated from solid-state fermentation of Pleurotus citrinopileatus. The structures of compounds 1-7 were determined by NMR and MS spectroscopic analysis. The absolute configuration of 1 was determined by X-ray diffraction analysis, while the absolute configurations of 3-7 were assigned using the in situ dimolybdenum circular dichroism method and circular dichroism data comparison. Protein tyrosine phosphatase 1B plays a crucial role as a negative regulator of the insulin-dependent signal cascades. Therefore, the protein tyrosine phosphatase 1B inhibitor can be used for treating type 2 diabetes mellitus and obesity. Compounds 2 and 6 showed moderate inhibitory effects on protein tyrosine phosphatase 1B with IC(50)s of 32.1 mu M and 30.5 mu M, respectively. The kinetic study confirmed compound 2 to be a noncompetitive inhibitor. Compounds 1-7 did not show cytotoxic activity against cancer cell lines (IC50 >50 mu M).

分类号： R9

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