High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to Chinese sheep

文献类型： 外文期刊

第一作者： Gorkhali, Neena Amatya

作者： Gorkhali, Neena Amatya;Jiang, Lin;He, Xiao-Hong;Qian Junzhao;Han, Jian-Lin;Ma, Yue-Hui;Gorkhali, Neena Amatya;Shrestha, Bhola Shankar;Han, Jian-Lin

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关键词： Heteroplasmy;mtDNA control region;Nepalese sheep;tandem repeats

期刊名称：MITOCHONDRIAL DNA PART A （ 影响因子：1.514； 五年影响因子：0.707 ）

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收录情况： SCI

摘要： Heteroplasmy due to length polymorphism with tandem repeats in mtDNAs within individual was hardly studied in domestic animals. In the present study, we identified intra-individual length variation in the control region of mtDNAs in Nepalese sheep by molecular cloning and sequencing techniques. We observed one to four tandem repeats of a 75-bp nucleotide sequences in the mtDNA control region in 45% of the total Nepalese sheep sampled in contrast to the Chinese sheep, indicating that the heteroplasmy isspecific to Nepalese sheep. The high rate of heteroplasmy in Nepalese sheep could be a resultant of the mtDNA mutation and independent segregation at intra-individual level or a strand slippage and mispairing during the replication.

分类号： Q7

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