AlCl3 induces lymphocyte apoptosis in rats through the mitochondria-caspase dependent pathway

文献类型： 外文期刊

第一作者： Li, Miao

作者： Li, Miao;Song, Miao;Ren, Li-Min;Xiu, Chun-Yu;Liu, Jian-Yu;Li, Yan-Fei;Liu, Jian-Yu;Zhu, Yan-zhu

作者机构：

关键词： aluminum;apoptosis;rat spleen lymphocytes;mitochondria;caspase

期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）

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年卷期：

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收录情况： SCI

摘要： To investigate apoptosis mechanisms in lymphocytes induced by aluminum trichloride (AlCl3) through the mitochondria-caspase dependent pathway, the spleen lymphocytes of rats were cultured with RPMI-1640 medium and exposed to AlCl(3)6H(2)O in the final concentrations of 0 (control group, CG), 0.3 (low-dose group, LG), 0.6 (mid-dose group, MG), and 1.2 (high-dose group, HG) mmolL(-1) for 24 h, respectively. Mitochondrial transmembrane potential (m), cytochrome C (Cyt C) protein expression in cytoplasm, Caspase-3 and Caspase-9 activity, Bcl-2, Bax, Caspase-3 and Caspase-9 mRNA expressions, DNA ladder and lymphocytes apoptosis index were detected. The results showed that Cyt C protein expression in cytoplasm, Caspase-3 and Caspase-9 activity, Bcl-2, Bax, Caspase-3 and Caspase-9 mRNA expressions, the ratio of Bcl-2 and Bax mRNA expression, lymphocytes apoptosis index increased, while m decreased in the AlCl3-treated groups compared with those in CG. The results indicate that AlCl3 induces lymphocyte apoptosis in rats through the mitochondria-caspase dependent pathway. (c) 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 385-394, 2016.

分类号： R9

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