New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against alpha-glucosidase and PTP1B

文献类型： 外文期刊

第一作者： Tao, Qiao-Qiao

作者： Tao, Qiao-Qiao;Ma, Ke;Bao, Li;Wang, Kai;Han, Jun-Jie;Liu, Hong-Wei;Tao, Qiao-Qiao;Zhang, Jin-Xia;Huang, Chen-Yang

作者机构：

关键词： Pleurotus cystidiosus;Sesquiterpenoids;Clitocybulol derivatives;Structure elucidation;PTP1B

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

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年卷期：

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收录情况： SCI

摘要： Nine new sesquiterpenoids, clitocybulol derivatives, clitocybulols G-O (1-9) and three known sesquiterpenoids, clitocybulols C-E (10 12), were isolated from the solid culture of the edible fungus Pleurotus cystidiosus. The structures of compounds 1-12 were determined by spectroscopic methods. The absolute configurations of compounds 1-9 were assigned via the circular dichroism (CD) data analysis. Compounds 1, 6 and 10 showed moderate inhibitory activity against protein tyrosine phosphatase-1B (PTP1B) with IC50 values of 49.5, 38.1 and 36.0 mu M, respectively. (C) 2016 Elsevier B.V. All rights reserved.

分类号： S759.82

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