Protective Efficacy of an H5N1 Inactivated Vaccine Against Challenge with Lethal H5N1, H5N2, H5N6, and H5N8 Influenza Viruses in Chickens

文献类型： 外文期刊

第一作者： Tian, Guobin

作者： Tian, Guobin;Chen, Hualan

作者机构：

关键词： avian influenza;H5N1 subtype;clade 2.3.4.4;inactivated vaccine;protective efficacy

期刊名称：AVIAN DISEASES （ 影响因子：1.577； 五年影响因子：1.915 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The Goose/Guangdong-lineage H5 viruses have evolved into diverse clades and subclades based on their hemagglutinin (HA) gene during their circulation in wild birds and poultry. Since late 2013, the clade 2.3.4.4 viruses have become widespread in poultry and wild bird populations around the world. Different subtypes of the clade 2.3.4.4 H5 viruses, including H5N1, H5N2, H5N6, and H5N8, have caused vast disease outbreaks in poultry in Asia, Europe, and North America. In this study, we developed a new H5N1 inactivated vaccine by using a seed virus (designated as Re-8) that contains the HA and NA genes from a clade 2.3.4.4 virus, A/chicken/Guizhou/4/13(H5N1) (CK/GZ/4/13), and its six internal genes from the high-growth A/Puerto Rico/8/1934 (H1N1) virus. We evaluated the protective efficacy of this vaccine in chickens challenged with one H5N1 clade 2.3.2.1b virus and six different subtypes of clade 2.3.4.4 viruses, including H5N1, H5N2, H5N6, and H5N8 strains. In the clade 2.3.2.1b virus DK/GX/S1017/13-challenged groups, half of the vaccinated chickens shed virus through the oropharynx and two birds (20%) died during the observation period. All of the control chickens shed viruses and died within 6 days of infection with challenge virus. All of the vaccinated chickens remained healthy following challenge with the six clade 2.3.4.4 viruses, and virus shedding was not detected from any of these birds; however, all of the control birds shed viruses and died within 4 days of challenge with the clade 2.3.4.4 viruses. Our results indicate that the Re-8 vaccine provides protection against different subtypes of clade 2.3.4.4 H5 viruses.

分类号： R36

  • 相关文献

[1]Protective Efficacy of the Inactivated H5N1 Influenza Vaccine Re-6 Against Different Clades of H5N1 Viruses Isolated in China and the Democratic People's Republic of Korea. Zeng, Xianying,Deng, Guohua,Liu, Liling,Li, Yanbing,Shi, Jianzhong,Chen, Pucheng,Feng, Huapeng,Tian, Guobin,Chen, Hualan,Zeng, Xianying,Deng, Guohua,Liu, Liling,Li, Yanbing,Shi, Jianzhong,Chen, Pucheng,Feng, Huapeng,Tian, Guobin,Chen, Hualan,Liu, Jingli,Guo, Xingfu,Mao, Shenggang,Yang, Fan,Chen, Zhiyu.

[2]DNA immunization elicits high HI antibody and protects chicken from AIV challenge. Chen, H,Yu, K,Jiang, Y,Tang, X. 2001

[3]An inactivated gE-deleted pseudorabies vaccine provides complete clinical protection and reduces virus shedding against challenge by a Chinese pseudorabies variant. Wang, Jichun,Guo, Rongli,Qiao, Yongfeng,Xu, Mengwei,Wang, Zhisheng,Liu, Yamei,Gu, Yiqi,Liu, Chang,Hou, Jibo,Gu, Yiqi,Liu, Chang,Wang, Jichun,Guo, Rongli,Qiao, Yongfeng,Xu, Mengwei,Wang, Zhisheng,Liu, Yamei,Hou, Jibo. 2016

[4]Immune response and protection in gibel carp, Carassius gibelio, after vaccination with beta-propiolactone inactivated cyprinid herpesvirus 2. Zhang, Linlin,Gu, Zemao,Zeng, Lingbing,Zhang, Linlin,Ma, Jie,Fan, Yuding,Zhou, Yong,Xu, Jin,Liu, Wenzhi,Zeng, Lingbing.

[5]Preparation and immunoprotection of subgroup B avian leukosis virus inactivated vaccine. Li, Xue,Dong, Xuan,Sun, Xiaolong,Li, Weihua,Zhao, Peng,Cui, Zhizhong,Li, Weihua,Wang, Xin. 2013

[6]Generation of a recombinant rabies Flury LEP virus carrying an additional G gene creates an improved seed virus for inactivated vaccine production. Tao, Lihong,Ge, Jinying,Wang, Xijun,Wen, Zhiyuan,Zhai, Hongyue,Hua, Tao,Zhao, Bolin,Kong, Dongni,Bu, Zhigao,Yang, Chinglai. 2011

[7]Foot-and-mouth disease vaccines: progress and problems. Cao, Yimei,Lu, Zengjun,Liu, Zaixin.

[8]Genetically modified rabies virus-vectored Ebola virus disease vaccines are safe and induce efficacious immune responses in mice and dogs. Shuai, Lei,Wang, Xijun,Wen, Zhiyuan,Ge, Jinying,Wang, Jinliang,Zhao, Dandan,Bu, Zhigao.

[9]Immunological responses and protection in Chinese giant salamander Andrias davidianus immunized with inactivated iridovirus. Liu, Wenzhi,Xu, Jin,Ma, Jie,Meng, Yan,Fan, Yuding,Zhou, Yong,Zeng, Lingbing,Liu, Wenzhi,Zeng, Lingbing,LaPatra, Scott E.,Yang, Xin.

[10]Inactivated vaccine with adjuvants consisting of pattern recognition receptor agonists confers protection against avian influenza viruses in chickens. Tang, Yinghua,Lu, Jihu,Wu, Peipei,Liu, Zhenxing,Tian, Zhen,Zha, Guofei,Chen, Hui,Wang, Qiaochu,Hou, Fengxiang,Hou, Jibo,Tang, Yinghua,Wang, Qiaoxiu,Kang, Sang-Moo.

[11]A novel M2e-multiple antigenic peptide providing heterologous protection in mice. Wen, Feng,Ma, Ji-Hong,Yu, Hai,Yang, Fu-Ru,Huang, Meng,Zhou, Yan-Jun,Li, Ze-Jun,Wang, Xiu-Hui,Li, Guo-Xin,Jiang, Yi-Feng,Tong, Wu,Tong, Guang-Zhi.

[12]Immunogenicity of a cell culture-derived inactivated vaccine against a common virulent isolate of grass carp reovirus. Zeng, Weiwei,Li, Shoujun,Zeng, Weiwei,Wang, Qing,Wang, Yingying,Zhao, Changchen,Li, Yingying,Shi, Chunbin,Wu, Shuqin,Song, Xinjian,Huang, Qiwen.

[13]Combined recombinant DNA vaccine results in significant protection against Mycobacterium tuberculosis. Pan, Y,Cai, H,Li, SX,Tian, X,Li, T,Zhu, YX. 2003

[14]Expression of truncated Babesia microti apical membrane protein 1 and rhoptry neck protein 2 and evaluation of their protective efficacy. Wang, Guanbo,Efstratiou, Artemis,Moumouni, Paul Franck Adjou,Liu, Mingming,Jirapattharasate, Charoonluk,Guo, Huanping,Gao, Yang,Suzuki, Hiroshi,Igarashi, Ikuo,Xuan, Xuenan,Cao, Shinuo,Zhou, Mo.

[15]Effects of different promoters on the protective efficacy of recombinant Marek's disease virus type 1 expressing the VP2 gene of infectious bursal disease virus. Li, Kai,Liu, Yongzhen,Liu, Changjun,Gao, Li,Zhang, Yanping,Gao, Yulong,Cui, Hongyu,Qi, Xiaole,Zhong, Li,Wang, Xiaomei.

[16]Protective efficacy of a novel recombinant Marek's disease virus vector vaccine against infectious bursal disease in chickens with or without maternal antibodies. Li, Kai,Liu, Yongzhen,Zhang, Yanping,Gao, Li,Liu, Changjun,Cui, Hongyu,Qi, Xiaole,Gao, Yulong,Zhong, Li,Wang, Xiaomei.

[17]Protective efficacy of a high-growth reassortant swine H3N2 inactivated vaccine constructed by reverse genetic manipulation. Wen, Feng,Ma, Ji-Hong,Yu, Hai,Yang, Fu-Ru,Huang, Meng,Zhou, Yan-Jun,Li, Ze-Jun,Tong, Guang-Zhi.

[18]Cross-protective efficacy of engineering serotype A foot-and-mouth disease virus vaccine against the two pandemic strains in swine. Zheng, Haixue,Lian, Kaiqi,Yang, Fan,Jin, Ye,Zhu, Zixiang,Guo, Jianhong,Cao, Weijun,Liu, Huanan,He, Jijun,Zhang, Keshan,Li, Dan,Liu, Xiangtao.

[19]A safe and molecular-tagged Brucella canis ghosts confer protection against virulent challenge in mice. Qian, Jing,Bu, Zhaoyang,Lang, Xulong,Wang, Xinglong,Qian, Jing,Qian, Jing,Yan, Guangmou,Yang, Yanling,Wang, Xiuran.

[20]Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD. Su, S.,Cui, N.,Sun, P.,Cui, Z.,Li, J.,Li, H.,Li, Y..

作者其他论文 更多>>

微信小程序