Inhibitory Effects of Metabolites of 5-Demethylnobiletin on Human Nonsmall Cell Lung Cancer Cells

文献类型: 外文期刊

第一作者: Song, Mingyue

作者: Song, Mingyue;Charoensinphon, Noppawat;Wu, Xian;Zheng, Jinkai;Gao, Zili;Xu, Fei;Wang, Minqi;Xiao, Hang;Xiao, Hang;Zheng, Jinkai

作者机构:

关键词: 5-demethylnobiletin;metabolites;nobiletin;lung cancer cells;chemoprevention

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )

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收录情况: SCI

摘要: 5-Demethylnobiletin is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers. We previously identified three metabolites of 5DN, namely 5,4'-didemethylnobiletin (M1), 5,3',4'-tridemethylnobiletin (M2), and 5,3'-didemethylnobiletin (M3) in mice fed 5DN. Herein, we investigated the inhibitory effects of these three metabolites on NSCLC cells. Our results demonstrated that M1, M2, and especially M3 showed stronger inhibition on the growth and colony formation of H460 and H1299 cells compared to 5DN. Three metabolites significantly inhibited the tumorsphere formation of A549 cells. Flow cytometry analysis showed that all metabolites induced cell cycle arrest and cellular apoptosis, and these effects were also stronger than that of 5DN. The inhibitory effects of these metabolites were associated with their ability to modulate the key signaling proteins related to cell proliferation and apoptosis. Overall, our results provided a basis for utilizing 5SDN and its metabolites for chemoprevention of lung cancer.

分类号: R15`S

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