6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortunei

文献类型： 外文期刊

第一作者： Lai, Yongji

作者： Lai, Yongji;Zeng, Hong;Qian, Huiqin;Wu, Zhaodi;Luo, Zengwei;Xue, Yongbo;Yao, Guangmin;Zhang, Yonghui;Lai, Yongji;He, Meijun

作者机构：

关键词： C-methyl-flavonoids;Structure elucidation;Neuroprotective effects;Rhododendron fortunei;Ericaceae

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

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收录情况： SCI

摘要： Six 6,8-di-C-methyl-flavonoids, (2R,3R)-6,8-di-C-methyl-5,7,4'-trihydroxyflavanonol 7-O-beta-D-gluco-pyranoside (1), (2R,3R)-6,8-di-C-methy1-5,7,4'-trihydroxyflavanonol 7-O-beta-D-xylopyranosyl(1 -> 6)-beta-D-glucopyranoside (2), 6,8-di-C-methylkaempferol 7-O-beta-D-glucopyranoside (3), (2R)-farrerol (4a), (2R/2S)-farrerol 7-O-beta-D-glucopyranoside (5), and (2R/2S)-farrerol 7-O-beta-D-xylopyranosyl(1 -> 6)-beta-D-glucopyranoside (6), and four known analogues, farrerol (4b), (2R,3R)-6,8-di-C-methyldihydrokae-mpferol (7), 6,8-di-C-methylkaempferol 7-O-beta-D-glucopyranoside (8), and 6,8-di-C-methylkaempferol (9), were isolated from the twigs and leaves of Rhododendron fortunei. The structures of compounds 1-9 were determined by spectroscopic analyses (HRESIMS, 1D and 2D NMR, and CD) and chemical methods. Compounds 1-9 were evaluated for their neuroprotective effects on the human neuroblastoma SH-SY5Y cells apoptosis induced by hydrogen peroxide (H2O2) and amyloid beta peptide (A beta), respectively. Compounds 1-3 and 5-9 exhibited significant neuroprotective effects against H2O2-induced SH-SY5Y cell apoptosis, and compound 8 exhibited the strongest activity with a improvement of cell viability by about 30% at the concentration of 10 mu M. Compounds 1-9 showed significant neuroprotective effects against A beta-induced SH-SY5Y cell apoptosis. (C) 2016 Elsevier B.V. All rights reserved.

分类号： S759.82

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