Anti-inflammatory activities of phospholipase C inhibitor U73122: Inhibition of monocyte-to-macrophage transformation and LPS-induced pro-inflammatory cytokine expression

文献类型： 外文期刊

第一作者： Zhu, Qiyun

作者： Zhu, Qiyun;Zhu, Liqian;Yuan, Chen;Ma, Yan;Ding, Xiuyan;Zhu, Guoqiang;Zhu, Liqian;Yuan, Chen;Ma, Yan;Ding, Xiuyan;Zhu, Guoqiang

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关键词： Phospholipase C;U73122;Scavenger receptors;Pro-inflammatory cytokines

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

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收录情况： SCI

摘要： A wide range of biological processes are controlled by phospholipase C (PLC)/Ca(2 +) signaling, which could be blocked by PLC-specific inhibitor U73122. Whether inhibition of PLC with chemical inhibitor U73122 affects the inflammatory response in monocytes/macrophages is currently unknown. In this study, we demonstrated that U73122 inhibited PMA-induced in vitro differentiation of human promonocytic U937 cells into macrophages as reflected by the reduction of cell adherence and the decreased expression of macrophage specific marker CD163. It is possible that U73122 blocked PMA-induced adhesion of U937 cells partially by down regulation and inactivation of both Pyk2 and paxillin signaling. Furthermore, the expression of LPS-induced proinflammatory cytokines TNF-alpha and IL-1 beta was significantly blocked by U73122 in both dU937 cells and mouse primary peritoneal macrophages. These results suggest that PLC is involved in the sophisticated inflammatory response by monocytes/macrophages, and thereby chemical antagonists of PLC may be potential agents for the suppression of inflammatory response. (C) 2015 Elsevier B.V. All rights reserved.

分类号： R96

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