Synthesis, Fungicidal Activity and Mode of Action of 4-Phenyl-6-trifluoromethyl-2-aminopyrimidines against Botrytis cinerea

文献类型： 外文期刊

第一作者： Qi, Zhiqiu

作者： Qi, Zhiqiu;Ji, Mingshan;Li, Xinghai;Cui, Zining;Yan, Xiaojing

作者机构：

关键词： aminopyrimidines;fungicide;structure-activity relationship;mode of action

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Anilinopyrimidines are the main chemical agents for management of Botrytis cinerea. However, the drug resistance in fungi against this kind of compounds is very serious. To explore new potential fungicides against B. cinerea, a series of 4-phenyl-6-trifluoromethyl-2-amino-pyrimidine compounds (compounds III-1 to III-22) were synthesized, and their structures were confirmed by H-1-NMR, IR and MS. Most of these compounds possessed excellent fungicidal activity. The compounds III-3 and III-13 showed higher fungicidal activity than the positive control pyrimethanil on fructose gelatin agar (FGA), and compound III-3 on potato dextrose agar (PDA) indicated high activity compared to the positive control cyprodinil. In vivo greenhouse results indicated that the activity of compounds III-3, III-8, and III-11 was significantly higher than that of the fungicide pyrimethanil. Scanning electron micrography (SEM) and transmission electron micrography (TEM) were applied to illustrate the mechanism of title compounds against B. cinerea. The title compounds, especially those containing a fluorine atom at the ortho-position on the benzene ring, could maintain the antifungal activity against B. cinerea, but their mechanism of action is different from that of cyprodinil. The present study lays a good foundation for us to find more efficient reagents against B. cinerea.

分类号： O62

  • 相关文献

[1]Antifungal activity of eugenol against Botrytis cinerea. Wang, Chunmei,Chen, Hao,Fan, Yongjian,Shi, Zhiqi,Wang, Chunmei,Chen, Hao,Fan, Yongjian,Shi, Zhiqi,Wang, Chunmei,Chen, Hao,Fan, Yongjian,Shi, Zhiqi,Zhang, Jie. 2010

[2]Antiviral effects against EV71 of pimprinine and its derivatives isolated from Streptomyces sp. Wei, Yanhong,Yang, Qingyu,Yang, Ziwen,Fang, Wei,Wan, Zhongyi,Wang, Kaimei,Shi, Liqiao,Yang, Ziwen,Cai, Xiaofeng. 2014

[3]Primary Study on Mode of Action for Macrocyclic Fungicide Candidates (7B3, D1) against Rhizoctonia solani Kuhn. Yuan, Huizhu,Qi, Shuhua,Yan, Xiaojing,Liang, Xiaomei,Jin, Shuhui,Lv, Jinping,Yu, Chunxin,Qi, Wenyan,Wu, Jingping,Chen, Fuheng,Wang, Daoquan,Li, Baoju,Shi, Yanxia. 2010

[4]Control of postharvest soft rot caused by Erwinia carotovora of vegetables by a strain of Bacillus amyloliquefaciens and its potential modes of action. Zhao, Yancun,Li, Pengxia,Huang, Kaihong,Wang, Yuning,Hu, Huali,Sun, Ya.

[5]In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants. Chen, Yan,Sun, Fang,Han, Han,Zhang, Xu,Fan, Yuying,Tai, Guihua,Zhou, Yifa,Chen, Yan,Li, Shengyu. 2010

[6]Synthesis and insecticidal activities of novel oxime ether pyrethroids. Ou, XM,Huang, MZ,Wang, XG,Liu, XP,Wang, YJ,Chen, C,Yao, JR.

[7]Design, synthesis and fungicidal activity of 11-alkoxyimino-5,6-dihydro-dibenzo[b,e] azepine-6-one derivatives. Xu, Yan-jun,Huang, Jia-xing,Liang, Xiao-mei,Zhang, Jian-jun,Wang, Dao-quan,Yan, Xiao-jing,Yuan, Hui-zhu.

[8]Design, synthesis and bioactivity evaluation of novel acylthiourea derivatives of cantharidin. Wang, Mei-Juan,Nan, Xiang,Liu, Ying-Qian,Yu, Hai-Tao,Hu, Guan-Fang,Feng, Gang. 2014

[9]Design of novel carbamate acetylcholinesterase inhibitors based on the multiple binding sites of acetylcholinesterase. Mei, Xiangdong,Yuan, Huizhu,Ning, Jun,Zhao, Qianfei.

[10]Structures and Mechanism of Action for Complex III Inhibiting-Fungicides. Hou Yuxia,Qin Zhaohai,Yuan Huizhu. 2010

[11]Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors. Zhang, Tao,Zhang, Lanxiang,Mei, Xiangdong,Dong, Mengya,Zhang, Kaixin,Ning, Jun.

[12]Spirodiclofen Analogues as Potential Lipid Biosynthesis Inhibitors: A Convenient Synthesis, Biological Evaluation, and Structure-Activity Relationship. Ke, Shaoyong,Sun, Tingting,Zhang, Zhigang,Zhang, Ya-Ni,Liang, Ying,Wang, Kaimei,Yang, Ziwen.

[13]Design, synthesis and bioactivity evaluation of novel benzophenone hydrazone derivatives. Li, Wen-Qun,Zhang, Zhi-Jun,Nan, Xiang,Liu, Ying-Qian,Zhao, Xiao-Bo,Wu, Dan,Yan, Li-Ting,Hu, Guan-Fang,Yu, Hai-Tao.

[14]Research Progress in Structure-Activity Relationship of Bioactive Peptides. Li, Ying,Yu, Jianmei,Li, Ying.

[15]Design, synthesis and fungicidal activity of novel 2-substituted aminocycloalkylsulfonamides. Wang, Minlong,Qin, Peiwen,Qi, Zhiqiu,Ji, Mingshan,Li, Xinghai,Liu, Xingyu,Babu, P. Vijaya,Cui, Zi-Ning,Yan, Xiaojing.

[16]Effects of exposure to sublethal propiconazole on the antioxidant defense system and Na+-K+-ATPase activity in brain of rainbow trout, Oncorhynchus mykiss. Li, Zhi-Hua,Zlabek, Vladimir,Grabic, Roman,Li, Ping,Machova, Jana,Velisek, Josef,Randak, Tomas,Li, Zhi-Hua,Li, Ping,Grabic, Roman. 2010

[17]Dynamic residual pattern of azoxystrobin in Swiss chard with contribution to safety evaluation. Farha, Waziha,Rahman, Md. Musfiqur,Kabir, Md. Humayun,Chung, Hyung Suk,Lee, Han Sol,Shim, Jae-Han,Abd El-Aty, A. M.,Abd El-Aty, A. M.,Shin, Ho-Chul,Jeon, Jong-Sup,Wang, Jing,Chang, Byung-Joon. 2018

[18]Dissipation kinetics and residue of LH-2010A in cucumber and soil under greenhouse condition. Li, Ruijuan,Liu, Tongjin,Song, Guochun,Li, Rumei,Yu, Jianlei. 2015

[19]Residue behavior and dietary intake risk assessment of three fungicides in tomatoes (Lycopersicon esculentum Mill.) under greenhouse conditions. Zhu, Xiaodan,Jia, Chunhong,Yu, Pingzhong,He, Min,Chen, Li,Zhao, Ercheng,Duan, Lifang,Zhang, Wei. 2016

[20]Ionic Liquid-Based Dispersive Liquid-Liquid Microextraction Following High-Performance Liquid Chromatography for the Determination of Fungicides in Fruit Juices. Wang, Suli,Yang, Suping,Wang, Suli,Liu, Congyun,Liu, Fengmao,Liu, Congyun. 2013

作者其他论文 更多>>

微信小程序