Probiotic potential of Lactobacillus paracasei FM-LP-4 isolated from Xinjiang camel milk yoghurt

文献类型： 外文期刊

第一作者： Wang, Ying

作者： Wang, Ying;Shao, Weilan;Wang, Ying;Zhou, Jianzhong;Xia, Xiudong;Zhao, Yancun

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期刊名称：INTERNATIONAL DAIRY JOURNAL （ 影响因子：3.032； 五年影响因子：3.395 ）

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收录情况： SCI

摘要： Fifty three probiotic lactic acid bacteria (LAB) strains with high anti-oxidative activity from Xinjiang camel milk yoghurt were screened and identified. Four strains showed higher 2,2-diphenyl-1-picrylhydrazyl scavenging activity and reducing power than the reference strain Lactobacillus rhamnosus GG (ATCC53103) with strain FM-LP-4, identified as Lactobacillus paracasei by 16S rDNA nucleotide sequencing, showing the highest. Strain FM-LP-4 also showed higher stress tolerance properties (acidity, bile, and osmotic pressure) and adhesion properties than L. rhamnosus GG. The in vivo antioxidant activity of FM-LP-4 was further assayed in D-galactose-induced oxidative damaged mice. Administration of FM-LP-4 significantly enhanced the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and inhibited the biosynthesis of malondialdehyde (MDA) and protein carbonyl in a dose-dependent manner. Additionally, FM-LP-4 strain could significantly decrease the endotoxin level in the serum of mice. Overall, strain FM-LP-4 is a promising probiotic candidate for preparations of functional foods and antioxidant supplements. (C) 2016 Elsevier Ltd. All rights reserved.

分类号： TS252

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