Comparative proteomic and bioinformatic analysis of Theileria luwenshuni and Theileria uilenbergi

文献类型： 外文期刊

第一作者： Zhang, Xiao

作者： Zhang, Xiao;Li, Youquan;Chen, Ze;Liu, Zhijie;Ren, Qiaoyun;Yang, Jifei;Zhu, Xinquan;Guan, Guiquan;Liu, Aihong;Luo, Jianxun;Yin, Hong;Zhang, Xiao;Li, Youquan;Chen, Ze;Liu, Zhijie;Ren, Qiaoyun;Yang, Jifei;Zhu, Xinquan;Guan, Guiquan;Liu, Aihong;Luo, Jianxun;Yin, Hong;Zhang, Xiao;Li, Youquan;Chen, Ze;Liu, Zhijie;Ren, Qiaoyun;Yang, Jifei;Zhu, Xinquan;Guan, Guiquan;Liu, Aihong;Luo, Jianxun;Yin, Hong

作者机构：

关键词： Comparative proteomics;Drug targets;Energy metabolism;Enzyme;Theileria

期刊名称：EXPERIMENTAL PARASITOLOGY （ 影响因子：2.011； 五年影响因子：2.132 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Theileria is an obligatory intraerythrocytic protozoan parasite that causes economic losses to the cattle, sheep and goats industry. However, very little information is available on the genomes, transcriptomes, and proteomes of the ovine parasites, Theileria luwenshuni and Theileria uilenbergi. Differences in protein expression between these species were investigated to better understand their biology. Parasites were digested with trypsin, and the resulting peptides labeled with isobaric tags for relative and absolute quantification, followed by LC-MS/MS. More than 670 proteins, classified into categories primarily related to cellular process (29.78%), metabolic process (28.80%), localization (5.22%) and biological regulation (5.00%), were identified. Seventy-one proteins were differentially expressed; T. luwenshuni had 39 proteins more highly expressed than in T. uilenbergi, whereas T. uilenbergi had 32 that were more highly expressed. Several proteins related to parasite virulence and invasion (cysteine proteinase, histone deacetylase, pyruvate kinase, small nuclear ribonucleoprotein and orotate phosphoribosyltransferase) were differentially expressed. Real-time quantitative PCR validated protein expression changes at the transcript level. This is the first report on protein expression for the two most economically important Theileria species in China, and our findings may provide novel opportunities for ovine and caprine theileriosis control. (C) 2016 Elsevier Inc. All rights reserved.

分类号： Q958.9

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