Analysis of miRNA expression profiling in mouse spleen affected by acute Toxoplasma gondii infection

文献类型： 外文期刊

第一作者： He, Jun-Jun

作者： He, Jun-Jun;Ma, Jun;Wang, Jin-Lei;Xu, Min-Jun;Zhu, Xing-Quan;Ma, Jun;Xu, Min-Jun;Zhu, Xing-Quan

作者机构：

关键词： Toxoplasma gondii;MicroRNA (miRNA);Spleen;Mouse

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.342； 五年影响因子：3.188 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Toxoplasma gondii is a worldwide prevalent pathogen that infects most of the warm-blood vertebrates. To investigate the regulation network of splenic miRNAs altered by acute infection with T. gondii, we herein investigated the changes of miRNA profile in mouse spleen via next generation sequencing and bioinformatics analysis. A total of 379 miRNAs was identified, 131 miRNAs of them were differentially expressed (including 97 upregulated and 34 downregulated miRNAs). 48 differentially expressed miRNAs had validated targets in the miRWalk2.0 database. Gene Ontology (GO) enrichment analysis revealed that the validated targets of differently expressed miRNAs were significantly enriched in gene transcription regulation. It suggested that T. gondii can modulate host gene expression through targeting to trans-regulation factors. The genes involved in apoptosis or antiapoptosis were both targeted by differentially expressed miRNAs. The change of power balance between the miRNAs targeting host apoptosis genes and those regulating host anti-apoptosis genes contributes to the fate of host apoptosis process. Twelve pathways were significantly enriched in KEGG analysis with most of them being cancer related, including pathways in cancer, pancreatic cancer, colorectal cancer, axon guidance, MAPK signaling pathway, focal adhesion, chronic myeloid leukemia, renal cell carcinoma, prostate cancer, glioma, regulation of actin cytoskeleton, and Wnt signaling pathway. Our study showed a changed miRNA regulation network in mouse spleen infected by T. gondii. These findings will be helpful for better understanding of miRNA regulation network in host-T. gondii interaction, revealing the relationship among T. gondii infection, gene regulation, apoptosis and cancer process alterations in infected spleen. (C) 2015 Elsevier B.V. All rights reserved.

分类号： R1

  • 相关文献

[1]Characterization of mouse brain microRNAs after infection with cyst-forming Toxoplasma gondii. Xu, Min-Jun,Zhou, Dong-Hui,Huang, Si-Yang,Fan, Yi-Fan,Zhu, Xing-Quan,Nisbet, Alasdair J.,Zhu, Xing-Quan,Fan, Yi-Fan. 2013

[2]Transcriptional changes of mouse splenocyte organelle components following acute infection with Toxoplasma gondii. He, Jun-Jun,Ma, Jun,Li, Fa-Cai,Song, Hui-Qun,Xu, Min-Jun,Zhu, Xing-Quan,Ma, Jun,Xu, Min-Jun.

[3]Comparative characterization of microRNA profiles of different genotypes of Toxoplasma gondii. Xu, M. J.,Zhou, D. H.,Huang, S. Y.,Zhao, F. R.,Song, H. Q.,Zhu, X. Q.,Xu, M. J.,Zhou, D. H.,Huang, S. Y.,Zhao, F. R.,Song, H. Q.,Zhu, X. Q.,Nisbet, A. J.,Lin, R. Q.,Zhu, X. Q.. 2013

[4]Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis. Chen, Xiao-Qing,Hu, Gui-Xue,Chen, Xiao-Qing,Zhou, Chun-Xue,He, Shuai,Zhu, Xing-Quan,Zhou, Chun-Xue,Elsheikha, Hany M.,He, Shuai. 2017

[5]Comparative analysis of microRNAs from the lungs and trachea of dogs (Canis familiaris) infected with canine influenza virus. Su, Shuo,Zhou, Pei,Xu, Ting-Chuan,Zhang, Liang-Quan,Cao, Nan,Qi, Wen-Bao,Zhang, Gui-Hong,Li, Shou-Jun,Zhao, Fu-Rong,Zhou, Dong-Hui. 2014

[6]Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum. Shao, Chang-Chun,Tao, Jian-Ping,Shao, Chang-Chun,Xu, Min-Jun,Song, Hui-Qun,Zhu, Xing-Quan,Alasaad, Samer,Peng, Lifei. 2014

[7]Identification and characterization of microRNAs in the pancreatic fluke Eurytrema pancreaticum. Xu, Min-Jun,Huang, Si-Yang,Fu, Jing-Hua,Zhou, Dong-Hui,Zhu, Xing-Quan,Wang, Chun-Ren,Chang, Qiao-Cheng,Zheng, Xu,Zhu, Xing-Quan,Fu, Jing-Hua,Zhu, Xing-Quan. 2013

[8]Global characterization of microRNAs in Trichomonas gallinae. Xu, Min-Jun,Qiu, Shen-Ben,Fu, Jing-Hua,Zhu, Xing-Quan,Nisbet, Alasdair J.,Qiu, Shen-Ben,Fu, Jing-Hua,Shao, Chang-Chun. 2014

[9]Identification and characterization of microRNAs in Baylisascaris schroederi of the giant panda. Zhao, Guang-Hui,Xu, Min-Jun,Zhu, Xing-Quan. 2013

[10]Overexpression of microRNA gga-miR-21 in chicken fibroblasts suppresses replication of infectious bursal disease virus through inhibiting VP1 translation. Ouyang, Wei,Pan, Qun-xing,Wang, Xiao-li,Xia, Xing-xia,Bi, Zhen-wei,Wang, Yong-qiang,Wang, Xiao-mei.

[11]Identification and characterization of microRNAs by deep-sequencing in Hyalomma anatolicum anatolicum (Acari: Ixodidae) ticks. Luo, Jin,Liu, Guang-Yuan,Chen, Ze,Ren, Qiao-Yun,Yin, Hong,Luo, Jian-Xun,Wang, Hui,Yin, Hong,Wang, Hui,Wang, Hui.

[12]Analysis of promoters of microRNAs from a Glycine max degradome library. Han, Yi-qiang,Gao, Ya-mei,Hu, Zheng,Zheng, Dian-feng. 2014

[13]Identification of microRNAs and their mRNA targets during soybean nodule development: functional analysis of the role of miR393j-3p in soybean nodulation. Yan, Zhe,Hossain, Md Shakhawat,Valdes-Lopez, Oswaldo,Wang, Jun,Libault, Marc,Stacey, Gary,Yan, Zhe,Hossain, Md Shakhawat,Valdes-Lopez, Oswaldo,Wang, Jun,Libault, Marc,Stacey, Gary,Arikit, Siwaret,Zhai, Jixian,Meyers, Blake C.,Arikit, Siwaret,Zhai, Jixian,Meyers, Blake C.,Wang, Jun,Qiu, Lijuan,Ji, Tieming.

[14]MicroRNAs Involved in the Pathogenesis of Phytophthora Root Rot of Soybean (Glycine max). Wang Jing,Zhang Li-wei,Wang Jia-lin,Chen Qing-shan,Liu Chun-yan,Hu Guo-hua,Ding Jun-jie. 2011

[15]Transcriptome analysis of the spleen of the darkbarbel catfish Pelteobagrus vachellii in response to Aeromonas hydrophila infection. Wen, Zhengyong,Yuan, Dengyue,Shao, Ting,Wang, Jun,Li, Huatao,Gong, Quan. 2017

[16]Expression analyses and antiviral properties of the Beijing-You and White Leghorn myxovirus resistance gene with different amino acids at position 631. Du, L. X.,Zhao, G. P.,Zhang, C. S..

[17]GlobalgeneexpressionprofileofchickenspleentissueatalaterstageofIBVinfectionrevealspathogenesisandimmunemechanisms. FengCong,ZongxiHan,FengjieWang,YuhaoShao,XiangangKong,ShengwangLiu. 2014

[18]Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats. Zhu, Yanzhu,Li, Yanfei,Zhu, Yanzhu,Miao, Liguang,Li, Xinwei,Chen, Chongxiao,Wang, Fan,Li, Jing,Hu, Chongwei. 2012

[19]Splenic microRNA Expression Profiles and Integration Analyses Involved in Host Responses to Salmonella enteritidis Infection in Chickens. Li, Peng,Fan, Wenlei,Li, Qinghe,Wang, Jie,Liu, Ranran,Liu, Jie,Zheng, Maiqing,Cui, Huanxian,Zhao, Guiping,Wen, Jie,Li, Peng,Everaert, Nadia,Li, Peng,Wang, Jie,Liu, Jie,Wen, Jie,Zhang, Yonghong. 2017

[20]Effects of Al on the splenic immune function and NE in rats. Hu, Chongwei,Li, Jing,Hu, Chongwei,Zhu, Yanzhu,Bai, Chongsheng,Zhang, Jihong,Xia, Shiliang,Li, Yanfei,Zhu, Yanzhu. 2013

作者其他论文 更多>>

微信小程序