Colletotrilactam A-D, novel lactams from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla
文献类型: 外文期刊
第一作者: Wei, Bo
作者: Wei, Bo;Yang, Zhong-Duo;Chen, Xiao-wei;Sun, Jing-Yun;Wang, Yong-gang;Xue, Hong-Yan;Wei, Bo;Zhou, Shuang-Yan;Yao, Xiao-Jun;Yu, Hai-Tao
作者机构:
关键词: Uncaria rhynchophylla;Rubiaceae;Colletotrichum gloeosporioides;Lactams;Colletotrilactam;Monoamine oxidase inhibitors
期刊名称:FITOTERAPIA ( 影响因子:2.882; 五年影响因子:3.202 )
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收录情况: SCI
摘要: Four novel lactams, colletotrilactam A-D (1-4), along with six known compounds (5-10) were isolated from the culture broth of Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla. The structures of these compounds were elucidated by comprehensive NMR spectroscopy. Isolates were tested for monoamine oxidase (MAO) inhibitory activity and compound 9 showed potent MAO inhibitory activity with IC50 value of 8.93 +/- 0.34 mu g/mL, when the IC50 value of iproniazid as a standard was 1.80 +/- 0.5 mu g/mL. (C) 2016 Elsevier B.V. All rights reserved.
分类号: S759.82
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