Exploring genotype-phenotype relationships of the LHX3 gene on growth traits in beef cattle
文献类型: 外文期刊
第一作者: Huang, Yong-Zhen
作者: Huang, Yong-Zhen;Jing, Yong-Jie;Sun, Yu-Jia;Lan, Xian-Yong;Chen, Hong;Zhang, Chun-Lei;Song, En-Liang
作者机构:
关键词: Association analyses;Cattle;Growth trait;Haplotype;LHX3
期刊名称:GENE ( 影响因子:3.688; 五年影响因子:3.329 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The LIM-homeobox gene 3 (LHX3) plays an essential role in pituitary gland and nervous system development. Sequence variants (SVs) in coding and non-coding regions of LHX3 gene have an impact on LHX3 transcription and growth traits in cattle. Previously, we have identified 3 single nucleotide polymorphisms (SNPs: 1-3) in all exons and intron 2 regions of the LHX3 gene in cattle. Here, 7 novel SNPs (SNPs: 4-10) were identified by DNA sequencing and polymerase chain reaction single-stranded conformational polymorphism (PCR-SSCP) methods. In the present study, a total of 10 SNPs were assessed linkage disequilibrium (LD) in 802 cows representing four main cattle breeds from China (Nanyang, Qinchuan, Jiaxian, and Chinese Holstein). The assessment results demonstrated that 17 haplotypes and 18 diplotypes were revealed in these cattle populations. Moreover, association analysis indicated that the genotypes of SNPs 1-6 are associated with the body weight at 6, 12 and 18. months of age in Nanyang cattle (P < 0.01 or P < 0.05), whereas no significant association was found between the 18 diplotypes and growth traits. Our results provide evidence that some SNPs in LHX3 gene may be associated with body weight at certain age, and LHX3 gene may be used as candidate gene for marker-assisted selection (MAS) in beef cattle breeding.
分类号: R394
- 相关文献
作者其他论文 更多>>
-
Adsorption effect and mechanism of Cd(II) by different phosphorus-enriched biochars
作者:Zeng, Yang;Lin, Yuhan;Ma, Ming;Chen, Hong;Ma, Ming;Chen, Hong;Ma, Ming;Chen, Hong
关键词:Phosphorous-enriched biochar; Agricultural and forestry waste; Low-grade phosphate rock and derivatives; Cadmium; Adsorption mechanism; Mineral precipitation
-
Zearalenone Decreases Food Intake by Disrupting the Gut-Liver-Hypothalamus Axis Signaling via Bile Acids
作者:Yuan, Peiqiang;Ma, Rongman;Huang, Jiancai;Wen, Hongmei;Huang, Lingjie;Li, Hua;Feng, Bin;Zhang, Xiaoling;Lin, Yan;Xu, Shengyu;Li, Jian;Zhuo, Yong;Hua, Lun;Che, Lianqiang;Wu, De;Fang, Zhengfeng;Yuan, Peiqiang;Hu, Liang;Li, Ran;Huang, Lingjie;Chen, Hong;Liu, Yuntao;Fang, Zhengfeng;Wang, Peng;Lin, Sen
关键词:zearalenone; bile acid metabolism; toxicity; farnesoid X receptor; food intake
-
Bovine enhancer-regulated circSGCB acts as a ceRNA to regulate skeletal muscle development via enhancing KLF3 expression
作者:Xu, Jiawei;Wen, Yifan;Li, Xinmiao;Yang, Peng;Chen, Ningbo;Lei, Chuzhao;Chen, Hong;Huang, Yongzhen;Peng, Wei;Zhang, Jun;Zhang, Zijing;Wang, Eryao;Liu, Xian;Huang, Yongzhen
关键词:circSGCB; ceRNA mechanism; Enhancer; KLF3; Muscle development
-
Error Risk Minimization
作者:Chen, Hong;Zhang, Xuelin;Chen, Hong;Zhang, Xuelin;Gong, Tieliang;Gu, Bin;Zheng, Feng;Chen, Hong;Chen, Hong;Zhang, Xuelin;Gong, Tieliang;Gu, Bin;Zheng, Feng;Gong, Tieliang;Gu, Bin;Zheng, Feng
关键词:Error density; Robust estimation; Kernel regression; Empirical risk minimization
-
Spatial differentiation characteristics of the Hemiptera insects in China
作者:Li, Zhipeng;Zhang, Xinyi;Zhao, Jian;Chen, Hong;Tian, Maofen;Tian, Maofen
关键词:geographical detector; Hemiptera insects; hot spot analysis; influencing factors; spatial autocorrelation; spatial distribution
-
A Review on the Removal of Heavy Metals from Water by Phosphorus-Enriched Biochar
作者:Zeng, Yang;Lin, Yuhan;Ma, Ming;Chen, Hong;Ma, Ming;Chen, Hong;Ma, Ming;Chen, Hong
关键词:phosphorus-rich biochar; precursor; carbonization process; adsorption mechanism
-
Neural partially linear additive model
作者:Zhu, Liangxuan;Li, Han;Zhang, Xuelin;Wu, Lingjuan;Chen, Hong;Chen, Hong;Chen, Hong;Chen, Hong
关键词:feature selection; structure discovery; partially linear additive model; neural network