(p)ppGpp synthetases regulate the pathogenesis of zoonotic Streptococcus suis

文献类型： 外文期刊

第一作者： Zhu, Jiawen

作者： Zhu, Jiawen;Zhang, Tengfei;Su, Zhipeng;Li, Lu;Wang, Dong;Xiao, Ran;Teng, Muye;Tan, Meifang;Zhou, Rui;Zhang, Tengfei;Li, Lu;Zhou, Rui

作者机构：

关键词： Streptococcus suis;(p)ppGpp synthetases;Stringent response;Pathogenesis

期刊名称：MICROBIOLOGICAL RESEARCH （ 影响因子：5.415； 五年影响因子：6.038 ）

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收录情况： SCI

摘要： (p)ppGpp-mediated stringent response is one of the main adaption mechanism in bacteria, and the ability to adapt to environment is linked to the pathogenesis of bacterial pathogens. In the zoonotic pathogen Streptococcus suis, there are two (p)ppGpp synthetases, RelA and RelQ. To investigate the regulatory functions of (p)ppGpp/(p)ppGpp synthetases on the pathogenesis of S. suis, the phenotypes of the [(p)ppGpp(0)] mutant Delta relA Delta relQ and its parental strain were compared. Light and electron microscopy observation showed that the mutant strain had a longer chain-length than its parental strain. Disruption of relA and relQ led to decreased adhesive and invasive ability to HEp-2 cells, and increased sensitivity to the blood killing and phagocytosis. Mouse infection experiments showed that the mutant strain was attenuated and easier to be cleaned up in vivo. Quantitative reverse transcription PCR (qRT-PCR) analysis indicated that the expressions of virulence related genes involving in morphology and virulence were down-regulated in the mutant strain. Our study demonstrated that the (p)ppGpp synthetases or (p)ppGpp can regulate the pathogenesis of this important zoonotic pathogen. (C) 2016 Elsevier GmbH. All rights reserved.

分类号： Q

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