Multi-residue determination of 210 drugs in pork by ultra-high-performance liquid chromatography-tandem mass spectrometry

文献类型： 外文期刊

第一作者： Yin, Zhiqiang

作者： Yin, Zhiqiang;Chai, Tingting;Mu, Pengqian;Xu, Nana;Song, Yue;Wang, Xinlu;Jia, Qi;Qiu, Jing

作者机构：

关键词： Veterinary drugs;Residue;Screening;UPLC-MS/MS;Q-Trap

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.759； 五年影响因子：4.302 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： This paper presents a multi -residue analytical method for 210 drugs in pork using ultra -high-performance liquid chromatography-Q-Trap tandem mass spectrometry (UPLC MS/MS) within 20 min via positive ESI in scheduled multi-reaction monitoring (MRM) mode. The 210 drugs, belonging to 21 different chemical classes, included macrolides, sulfonamides, tetracyclines, beta-lactams, beta-agonists, aminoglycosides, antiviral drugs, glycosides, phenothiazine, protein anabolic hormones, non-steroidal anti-inflammatory drugs (NSAIDs), quinolones, antifungal drugs, corticosteroids, imidazoles, piperidines, piperazidines, insecticides, amides, alkaloids and others. A rapid and simple preparation method was applied to process the animal tissues, including solvent extraction with an acetonitrile/water mixture (80/20, v/v), defatting and clean-up processes. The recoveries ranged from 52% to 130% with relative standard deviations (RSDs) < 20% for spiked concentrations of 10, 50 and 250 mu g/kg. More than 90% of the analytes achieved low limits of quantification (LOQs) < 10 mu g/kg. The decision limit (CC alpha), detection capability (CC beta) values were in the range of 2-502 mu g/kg and 4-505 mu g/kg, respectively. This method is significant for food safety monitoring and controlling veterinary drug use. (C) 2016 Elsevier B.V. All rights reserved.

分类号： O65

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