Studies on the biological functions of CPS1 in AFS(1) induced hepatocarcinogenesis

文献类型： 外文期刊

第一作者： Yang, Chi

作者： Yang, Chi;Fu, Rao;Zhuang, Zhenhong;Wang, Shihua;Yang, Chi

作者机构：

关键词： Carbamyl phosphate synthetase I;Aflatoxin B-1;Hepatocarcinogenesis;Interacting protein

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Carbamyl phosphate synthetase 1 (CPS1) was down-regulated in hepatocellular carcinoma (HCC), as treated by aflatoxin B-1 (AFB(1)), a potent hepatocarcinogenesis mycotoxin. In this study, we firstly confirmed that AFB(1) down regulated the expression of CPS1 in a dose-dependent manner. At the meantime, both siRNA knock down of CPS1 and AFB(1), treatment inhibited cell proliferation, and induced cell apoptosis. To further analysis the function of CPS1, the interacting proteins of CPS1 were searched by Co-IP, and three interacting proteins including type II cytoskeletal 1 (KRT1), albumin (ALB), and ubiquitin C (UBC) were found. Both KRT1 and ALB were new interacting proteins for CPS1. Our further study showed that CPS1 was regulating interacted and colocalized with KRT1 and ALB, and the intensity correlation was changed by AFB1. KRT1, ALB and CPS1 were all reported to play an important role in differentiation and tissue specialization. These results may offer an increasing understand that CPS1 might have a function in differentiation. (C) 2016 Elsevier B.V. All rights reserved.

分类号： R394

  • 相关文献

[1]Structures of the Ozonolysis Products and Ozonolysis Pathway of Aflatoxin B-1 in Acetonitrile Solution. Diao, Enjie,Shan, Changpo,Hou, Hanxue,Dong, Haizhou,Wang, Shanshan,Li, Minghua. 2012

[2]Influence of Selenium on Hepatic Mitochondrial Antioxidant Capacity in Ducklings Intoxicated with Aflatoxin B-1. Shi, Dayou,Guo, Shining,Su, Rongsheng,Pan, Jiaqiang,Lin, Yuanchao,Tang, Zhaoxin,Liao, Shenquan. 2012

[3]Dual-competitive lateral flow aptasensor for detection of aflatoxin B-1 in food and feedstuffs. Zhu, Chao,Zhang, Guilan,Huang, Yafei,Yang, Shuming,Chen, Ailiang,Zhu, Chao,Zhang, Guilan,Huang, Yafei,Yang, Shuming,Chen, Ailiang,Huang, Yafei,Ren, Shuyue,Gao, Zhixian. 2018

[4]Influence of Longdan Xiegan Decoction on Body Weights and Immune Organ Indexes in Ducklings Intoxicated with Aflatoxin B-1. Guo, S. N.,Su, R. S.,Lin, R. Q.,Chen, Y. Z.,Tang, Z. X.,Shi, D. Y.,Wu, H.,Liao, S. Q.. 2012

[5]Influence of Selenium on Body Weights and Immune Organ Indexes in Ducklings Intoxicated with Aflatoxin B-1. Guo, Shining,Shi, Dayou,Su, Rongsheng,Lin, Yuanchao,Pan, Jiaqiang,Tang, Zhaoxin,Liao, Shenquan. 2012

[6]Influences of Selenium on the Duckling Hepatic Mitochondrial Membrane Permeability Changes Induced by Aflatoxin B-1. Shi, D. -Y.,Guo, S. -N.,Tang, Z. -X.,Liao, S. -Q.. 2011

[7]Detoxification of Aflatoxin B-1 by Zygosaccharomyces rouxii with Solid State Fermentation in Peanut Meal. Zhou, Guanghui,Chen, Yujie,Kong, Qing,Ma, Yunxiao,Liu, Yang. 2017

[8]Influences of Selenium on the Duckling Hepatic Mitochondrial Membrane Permeability Changes Induced by Aflatoxin B-1. Shi, D. -Y.,Guo, S. -N.,Liao, S. -Q.,Tang, Z. -X.. 2011

[9]Influences of Selenium on the Ducklings Hepatic Mitochondrial Respiratory Function Changes Induced by Aflatoxin B-1. Shi, Dayou,Guo, Shining,Tang, Zhaoxin,Liao, Shenquan. 2011

[10]Effect of drying treatments on anthocyanin, fumonisin B-1, aflatoxin B-1 content of anthocyanin extract from purple corn (Zea may L.) in north China. Zhang, Chao,Ma, Yue,Zhao, Xiaoyan,Wang, Fen. 2011

[11]Eu3+-labeled IgG-based time-resolved fluoroimmunoassay for highly sensitive detection of aflatoxin B-1 in feed. Zhang, Gaiping,Hu, Xiaofei,Yao, Jingjing,Wang, Fangyu,Yin, Mengqi,Sun, Yaning,Hu, Mei,Shi, Qiaoqiao,Zhang, Gaiping. 2018

[12]Influences of Traditional Chinese Medicine on the Ducklings Hepatic Mitochondrial Membrane Permeability Changes Induced by Aflatoxin B-1. Shi, Dayou,Guo, Shining,Tang, Zhaoxin,Liao, Shenquan. 2011

[13]Cinnamaldehyde inhibits fungal growth and aflatoxin B-1 biosynthesis by modulating the oxidative stress response of Aspergillus flavus. Sun, Qi,Shang, Bo,Liu, Yang,Wang, Ling,Lu, Zhisong.

[14]Quality Evaluation of Five Commercial Enzyme Linked Immunosorbent Assay Kits for Detecting Aflatoxin B-1 in Feedstuffs. Sun, Dan-dan,Gu, Xu,Li, Jun-guo,Yao, Ting,Dong, Ying-chao.

[15]Effect of storage treatments on anthocyanin, fumonisin B-1, aflatoxin B-1 content of anthocyanin extract from purple corn (Zea may L.) in north China. Zhang, Chao,Ma, Yue,Zhao, Xiaoyan,Wang, Fen. 2012

[16]Aflatoxin B-1 and sterigmatocystin in wheat and wheat products from supermarkets in China. Zhao, Yarong,Huang, Jianxiang,Chen, Zhihui,Wang, Fuhua,Zhao, Yarong,Ma, Liyan,Zhao, Yarong,Huang, Jianxiang,Chen, Zhihui,Wang, Fuhua,Zhao, Yarong,Huang, Jianxiang,Chen, Zhihui,Wang, Fuhua,Wang, Qiongshan. 2018

[17]Effects of feeding corn naturally contaminated with aflatoxin on growth performance, apparent ileal digestibility, serum hormones levels and gene expression of Na+, K+-ATPase in ducklings. Abbasi, Farzana,Liu, Jingbo,Shen, Xiaoyun,Luo, Xuegang,Liu, Jingbo,Zhang, Hongfu,Shen, Xiaoyun. 2018

[18]Risk Assessment on Dietary Exposure to Aflatoxin B-1 in Post-Harvest Peanuts in the Yangtze River Ecological Region. Ding, Xiaoxia,Wu, Linxia,Li, Peiwu,Zhang, Zhaowei,Zhou, Haiyan,Bai, Yizhen,Chen, Xiaomei,Jiang, Jun,Ding, Xiaoxia,Wu, Linxia,Li, Peiwu,Zhang, Zhaowei,Ding, Xiaoxia,Wu, Linxia,Li, Peiwu,Chen, Xiaomei,Jiang, Jun,Ding, Xiaoxia,Li, Peiwu,Zhang, Zhaowei,Zhou, Haiyan,Bai, Yizhen,Ding, Xiaoxia,Li, Peiwu,Zhang, Zhaowei,Zhou, Haiyan,Bai, Yizhen,Chen, Xiaomei,Jiang, Jun. 2015

[19]Aflatoxin B-1 in post-harvest peanuts and dietary risk in China. Ding, Xiaoxia,Li, Peiwu,Zhou, Haiyan,Ding, Xiaoxia,Li, Peiwu,Bai, Yizhen,Zhou, Haiyan,Ding, Xiaoxia,Li, Peiwu. 2012

[20]Monoclonal antibody-quantum dots CdTe conjugate-based fluoroimmunoassay for the determination of aflatoxin B-1 in peanuts. Zhang, Zhaowei,Li, Yuanyuan,Li, Peiwu,Zhang, Qi,Zhang, Wen,Hu, Xiaofeng,Ding, Xiaoxia,Zhang, Zhaowei,Li, Yuanyuan,Li, Peiwu,Hu, Xiaofeng,Ding, Xiaoxia,Zhang, Qi,Zhang, Zhaowei,Li, Peiwu,Li, Peiwu,Zhang, Wen. 2014

作者其他论文 更多>>

微信小程序