N-glycosylation proteomic characterization and cross-species comparison of milk fat globule membrane proteins from mammals

文献类型： 外文期刊

第一作者： Yang, Yongxin

作者： Yang, Yongxin;Zheng, Nan;Zhao, Xiaowei;Zhang, Yangdong;Han, Rongwei;Ma, Lu;Zhao, Shengguo;Li, Songli;Guo, Tongjun;Zang, Changjiang;Wang, Jiaqi;Yang, Yongxin;Zhao, Xiaowei;Wang, Weiyu

作者机构：

关键词： Animal proteomics;Animal species;Glycosylation;Milk fat globule membrane;Proteome

期刊名称：PROTEOMICS （ 影响因子：3.984； 五年影响因子：3.831 ）

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年卷期：

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收录情况： SCI

摘要： Glycosylation of proteins has been implicated in various biological functions and has received much attention; however, glycoprotein components and inter-species complexity have not yet been elucidated fully in milk proteins. N-linked glycosylation sites and glycoproteins in milk fat globule membrane (MFGM) fractions were investigated by combining N-glycosylated peptides enrichment and high-accuracy Q Exactive identification, to map the N-glycoproteome profiles in Holstein and Jersey cows, buffaloes, yaks, goats, camels, horses, and humans. A total of 399 N-glycoproteins with 677 glycosylation sites were identified in the MFGM fractions of the studied mammals. Most glycosylation sites in humans were classified as known and those in the other studied mammals as unknown, according to Swiss-Prot annotations. Functionally, most of the identified glycoproteins were associated with the response to stimulus' GO category. N-glycosylated protein components of MFGM fractions from Holstein and Jersey cows, buffaloes, yaks, and goats were more similar to each other compared with those of camels, horses and human. The findings increased the number of known N-glycosylation sites in the milk from dairy animal species, revealed the complexity of the MFGM glycoproteome, and provided useful information to further explore the mechanism of MFGM glycoproteins biosynthesis among the studied mammals.

分类号： Q5

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