Chiral separation of mandelic acid enantiomers using an aqueous two-phase system based on a thermo-sensitive polymer and dextran

文献类型： 外文期刊

第一作者： Tan, Zhijian

作者： Tan, Zhijian;Li, Fenfang;Zhao, Congcong;Teng, Yubin;Liu, Yanfei;Tan, Zhijian;Tan, Zhijian

作者机构：

关键词： Chiral separation;Thermo-sensitive polymer;Aqueous two-phase system;Mandenic acid enantiomers

期刊名称：SEPARATION AND PURIFICATION TECHNOLOGY （ 影响因子：7.312； 五年影响因子：6.656 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： In this study, a thermo-sensitive polymer Poly(MAH-beta-CD-co-NIPAAm) was synthesized by the copolymerization of N-isopropylazylamide (NIPAAm) with the maleic anhydride (MAH) modified beta-cyclodextrin (beta-CD). This polymer was both used as chiral selector and phase-forming component of aqueous two-phase system (ATPS). ATPS formed by Poly(MAH-beta-CD-co-NIPAAm) and dextran T40 was used for chiral separation of mandelic acid (MA) enantiomers. The influencing parameters of the distribution behavior of MA were studied, viz. concentration of thermo-sensitive polymer, pH, operational temperature, and initial MA concentration. The results showed that this chiral selector preferentially recognizes the (S)-enantiomer rather than the (R)-enantiomer, the maximum separation factor (cc) can reach to 1.27 under the optimum conditions. The thermo-sensitive polymer can be recycled by heating and centrifugation after enantioseparation. This ATPS is a simple, green and economical approach for the chiral separation of MA and other chiral enantiomers. (C) 2016 Elsevier B.V. All rights reserved.

分类号： TQ028`TQ546

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