The suppressive effects of aluminum chloride on the osteoblasts function

文献类型： 外文期刊

第一作者： Zhu, Yanzhu

作者： Zhu, Yanzhu;Yan, Xijun;Miao, Liguang;Li, Haitao;Lian, Shizhen;Feng, Zhuo;Xu, Feibo;Li, Yanfei;Hu, Chongwei;Wang, Zhongying

作者机构：

关键词： Aluminum;Osteoblasts viability;Anti-oxidative function;Growth regulation factors mRNA expressions;Ultrastructural features

期刊名称：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY （ 影响因子：4.86； 五年影响因子：4.462 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Aluminum (Al) exposure impairs bone formation, and bone formation is mediated by the osteoblasts. But effects of Al on the osteoblasts function remain elusive. The osteoblasts were exposed to 0, 0.0252, 0.126, 0.252 mg/mL AlCl3 center dot 6H(2)O for 24 h. The osteoblasts viability,TGF-beta(1), BMP-2, IGF-I and Cbf alpha 1 mRNA expressions, and GSH-P-x and SOD activities, ROS concentration were determined. The osteoblasts ultrastructural features were also observed. The results showed that AlCl3 suppressed the osteoblasts viability, TGF-beta(1), BMP-2, IGF-I and Cbf alpha 1 mRNA expressions, GSH-P-x and SOD activities, and elevated ROS concentration compared with the CG. The ultrastructural features of osteoblasts in the HG showed mitochondrial swelling, foam-like structure, uneven distribution of chromatin, incomplete cell membrane and cytoplasm spillover compared with the CG. It indicates that AlCl3 inhibits osteoblasts viability, growth regulation factors mRNA expressions, anti-oxidative function, and damaged the osteoblasts histology structure, impairing the osteoblasts function. (C) 2016 Elsevier B.V. All rights reserved.

分类号： R9

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