ZIP restores estrogen receptor expression and response to Tamoxifen in estrogen receptor negative tumors
文献类型: 外文期刊
第一作者: Zhu, Ning
作者: Zhu, Ning;Miao, Ruidong;Du, Yuping;Yang, Jinbo;Zhang, Jing;Qin, Xiaodong
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关键词: ZIP;ER-negative;Tamoxifen;In vivo
期刊名称:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ( 影响因子:3.575; 五年影响因子:3.381 )
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收录情况: SCI
摘要: As a component of NURD histone deacetylase complex, ZIP serves as a tumor suppressor gene in the development of breast tumors. However, whether it takes part in chemotherapy resistance remains poorly defined. In the present study, we reported that ZIP enhanced the response to SERM chemotherapy in ER-negative cells. Overexpression of ZIP suppressed EGFR expression level and restored ERalpha protein level in cells resistant to Tamoxifen. In vivo data confirmed those in vitro findings. (C) 2016 Elsevier Inc. All rights reserved.
分类号: Q5
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