Nuclear export signal of PRRSV NSP1 alpha is necessary for type I IFN inhibition
文献类型: 外文期刊
第一作者: Chen, Zhi
作者: Chen, Zhi;Liu, Shaoning;Sun, Wenbo;Chen, Lei;Ren, Sufang;Guo, Lihui;Cong, Xiaoyan;Li, Jun;Wu, Jiaqiang;Du, Yijun;Wang, Jinbao;Liu, Shaoning;Yoo, Dongwan;Li, Feng;Zhou, Shun
作者机构:
关键词: PRRSV;NSP1 alpha;Type I IFN;Nuclear export signal (NES)
期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )
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收录情况: SCI
摘要: The nonstructural protein 1 alpha (NSP1 alpha) of porcine reproductive and respiratory syndrome virus (PRRSV) is a nucleo-cytoplasmic protein that suppresses the production of type I interferon (IFN). In this study, we investigated the relationship between the subcellular distribution of NSP1 alpha and its inhibition of type I IFN. NSP1 alpha was found to contain the classical nuclear export signal (NES) and NSP1 alpha nuclear export was CRM-1-mediated. NSP1 alpha was shuttling between the nucleus and cytoplasm. We also showed that the nuclear export of NSP1 alpha was necessary for its ability for type I IFN inhibition. NSP1 alpha was also found to interact with CBP, which implies a possible mechanism of CBP degradation by NSP1 alpha. Taken together, our results describe a novel mechanism of PRRSV NSP1 alpha for type I IFN inhibition and suppression of the host innate antiviral response. (C) 2016 Published by Elsevier Inc.
分类号: R37
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