Identification of copy number variations in three Chinese horse breeds using 70K single nucleotide polymorphism BeadChip array

文献类型： 外文期刊

第一作者： Kader, Adiljan

作者： Kader, Adiljan;Liu, Xuexue;Dong, Kunzhe;Song, Shen;Pan, Jianfei;Yang, Min;Chen, Xiaofei;He, Xiaohong;Jiang, Lin;Ma, Yuehui;Kader, Adiljan;Dong, Kunzhe;Song, Shen

作者机构：

关键词： copy number variation region;Debao pony;growth;single nucleotide polymorphism array

期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）

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收录情况： SCI

摘要： Copy number variation (CNV), an essential form of genetic variation, has been increasingly recognized as one promising genetic marker in the analysis of animal genomes. Here, we used the Equine 70K single nucleotide polymorphism genotyping array for the genome-wide detection of CNVs in 96 horses from three diverse Chinese breeds: Debao pony (DB), Mongolian horse (MG) and Yili horse (YL). A total of 287 CNVs were determined and merged into 122 CNV regions (CNVRs) ranging from 199 bp to 2344 kb in size and distributed in a heterogeneous manner on chromosomes. These CNVRs were integrated with seven existing reports to generate a composite genome-wide dataset of 1558 equine CNVRs, revealing 69 (56.6%) novel CNVRs. The majority (69.7%) of the 122 CNVRs overlapped with 438 genes, whereas 30.3% were located in intergenic regions. Most of these genes were associated with common CNVRs, which were shared by divergent horse breeds. As many as 60, 42 and 91 genes overlapping with the breed-specific ss were identified in DB, MG and YL respectively. Among these genes, FGF11, SPEM1, PPARG, CIDEB, HIVEP1 and GALR may have potential relevance to breed-specific traits. These findings provide valuable information for understanding the equine genome and facilitating association studies of economically important traits with equine CNVRs in the future.

分类号： Q953

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