Oat products modulate the gut microbiota and produce anti-obesity effects in obese rats

文献类型： 外文期刊

第一作者： Dong, Ji-lin

作者： Dong, Ji-lin;Ma, Yu-ling;Xiang, Qi-sen;Shen, Rui-ling;Liu, Yan-qi;Dong, Ji-lin;Shen, Rui-ling;Zhu, Ying-ying;Zhu, Ying-ying

作者机构：

关键词： Oat products;Anti-obesity;TNF-alpha;Gut microflora;SCFA

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

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年卷期：

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收录情况： SCI

摘要： Three oat products were supplemented into high fat diets and fed to obese rats for 8 weeks. Each oat product decreased body weight, epididymal fat accumulation, and serum inflammatory factor levels and significantly regulated serum lipid levels. Oat bran significantly reduced mean adipocyte size and TNF-alpha mRNA expression levels. Principal components analysis showed that the oat products shifted the overall structure of gut microbiota in DIO rats. The relative abundances of Bacteroidetes and Firmicutes and the Bacteroidetes/Firmicutes ratio were altered towards that of normal rats. Spearman's correlation analysis showed that changes in the overall microbiota composition were significantly correlated with total cholesterol, triacylglycerol, endotoxin, and tumour cell necrosis factor-alpha levels in serum, and mRNA expression levels. Oat products significantly increased the total short-chain fatty acids (SCFA) concentration in colonic digesta. These results suggest that oat products attenuate obesity and related metabolic disorders while modifying the gut microbiota composition in high fat diet-induced obese rats. (C) 2016 Elsevier Ltd. All rights reserved.

分类号： TS2

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