Aluminum Chloride- and Norepinephrine-Induced Immunotoxicity on Splenic Lymphocytes by Activating beta(2)-AR/cAMP/PKA/NF-kappa B Signal Pathway in Rats

文献类型： 外文期刊

第一作者： Xiu, Chunyu

作者： Xiu, Chunyu;Ren, Limin;Li, Miao;Liu, Jianyu;Li, Yanfei;Liu, Shiming;Zhu, Yanzhu;Liu, Jianyu

作者机构：

关键词： NE;AlCl3;Immunotoxicity beta(2)-AR/cAMP/PKA/NF-kappa B pathway;Rat

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.738； 五年影响因子：3.44 ）

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年卷期：

页码：

收录情况： SCI

摘要： We found in our previous research that aluminum (Al) exposure induced immunotoxicity on spleen and increased norepinephrine (NE) content in serum from rats. However, it is unclear how NE is involved in the AlCl3 immunotoxicity on rats. Therefore, this experiment was designed to explore the mechanism of AlCl3 and NE-induced immunotoxicity on the splenic lymphocytes. Eighty male Wistar rats were orally exposed to AlCl3 (0, 64, 128, and 256 mg/kg BW) through drinking water for 120 days. Al contents in brain and spleen; NE contents in serum and in the hypothalamus; beta(2)-AR density; cAMP content; beta(2)-AR, PKA, and NF-kappa B mRNA expression levels; and protein expressions of PKA and nuclear NF-kappa B in splenic lymphocytes of AlCl3-treated rats were examined. The results showed that AlCl3 increased NE content in serum, the beta(2)-AR density, the beta(2)-AR and PKA (C-subunits) mRNA expression levels, cAMP content and the PKA (C-subunits) protein expression levels in lymphocytes, whereas, decreased NE content in the hypothalamus, the NF-kappa B (p65) mRNA expression level and nuclear NF-kappa B (p65) protein expression level in lymphocytes. These results indicated that the accumulated AlCl3 in spleen and the increased NE in serum induced the immunotoxicity on splenic lymphocytes by activating beta(2)-AR/cAMP/PKA/NF-kappa B signal pathway in rats.

分类号： Q5

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