Neuroprotective effect of crude polysaccharide isolated from the fruiting bodies of Morchella importuna against H2O2-induced PC12 cell cytotoxicity by reducing oxidative stress
文献类型: 外文期刊
第一作者: Li, Qiang
作者: Li, Qiang;Chen, Zuqin;Huang, Wenli;Chen, Cheng
作者机构:
关键词: Morchella importuna;Neuroprotective;Oxidative stress;Polysaccharide
期刊名称:BIOMEDICINE & PHARMACOTHERAPY ( 影响因子:6.529; 五年影响因子:5.979 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Oxidative stress played an essential role in neuronal cell injury through several apoptotic mechanisms associated with many neurodegenerative diseases. Reducing oxidative stress through antioxidants might be a possible strategy that could retard the disease's progression. In order to investigate the neuroprotective role of MIP (the crude polysaccharide extracted from the fruiting bodies of Morchella importuna), the antioxidative activity of MIP against the H2O2-induced cytotoxicity and the underlying preventative mechanisms in rat pheochromocytoma (PC12) cells were illustrated. It was shown that MIP could considerably enhance the viability of PC12 cells exposure to H2O2 and increased the activities of antioxidant enzyme like CAT, GSH-Px and SOD. It also reduced the content of malondialdehyde MDA and caspase-3 activation. In addition, MIP inhibited cell apoptosis via down-regulation of the NF-kappa B pathway and the p38-JNK pathway as well as activating of the extracellular signal-regulated kinase (ERK). Accordingly, MIP can be used as a promising neuroprotective compound for nervous diseases treatment. (C) 2016 Elsevier Masson SAS. All rights reserved.
分类号: R45
- 相关文献
作者其他论文 更多>>
-
Rabbitfish (Siganus oramin) gut microbiota description of farmed and wild specimens
作者:Huang, Xiaolin;Yang, Yukai;Huang, Zhong;Lin, Heizhao;Huang, Xiaolin;Yang, Yukai;Huang, Zhong;Lin, Heizhao;Li, Qiang;Li, Wenjun;Han, Chong
关键词:Rabbitfish; 16s rDNA; Gut microbiota; Artificial cultivation
-
Gut bacterial community of Cnaphalocrocis medinalis (Guenée) (Lepidoptera: Crambidae) is driven by rice varieties
作者:Lin, Sheng;Zhang, Bang;Li, Qiang;Li, Xue-wen;Jiao, Hui-yu;Lin, Sheng;Zhang, Bang;Li, Qiang;Li, Xue-wen;Jiao, Hui-yu;Lin, Sheng;Zhang, Bang;Li, Qiang;Li, Xue-wen;Jiao, Hui-yu;Lin, Sheng;Li, Qiang;Guo, Qi-tang;Chen, Wen-le;Akutse, Komivi Senyo;Akutse, Komivi Senyo;Zhu, Xiang-zhen;Lin, Sheng;Lin, Sheng;Akutse, Komivi Senyo;Zhu, Xiang-zhen
关键词:16S rRNA; bacterial diversity; diet-dependent bacteria; rice leaf folder
-
Pseudomonas hefeiensis sp. nov., isolated from the rhizosphere of multiple cash crops in China
作者:Liao, Kaiji;Li, Jun-Zhou;Wei, Hai - Lei;Liao, Kaiji;Li, Qiang
关键词:crops rhizosphere; plant growth- promoting rhizobacteria; polyphasic taxonomy; Pseudomonas
-
De Novo Assembly, Characterization, and Comparative Transcriptome Analysis of Mature Male and Female Gonads of Rabbitfish (Siganus oramin) (Bloch & Schneider, 1801)
作者:Huang, Xiaolin;Huang, Zhong;Yang, Yukai;Lin, Heizhao;Wu, Qiaer;Zhou, Yanbo;Huang, Xiaolin;Huang, Zhong;Yang, Yukai;Lin, Heizhao;Wu, Qiaer;Zhou, Yanbo;Li, Qiang;Li, Wenjun;Han, Chong
关键词:rabbitfish; transcriptome; gonad; reproduction-related genes
-
Effect of Pleurotus eryngii mycelial fermentation on the composition and antioxidant properties of tartary buckwheat
作者:Li, Lijiao;Huang, Jingwei;Zhang, Ting;Wu, Qian;Xiang, Peng;Zou, Liang;Li, Qiang;Cao, Xiaonian;Shen, Caihong;Cao, Xiaonian;Shen, Caihong;Li, Qiang;Huang, Jingwei;Li, Jun;Li, Qiang
关键词:Solid-state fermentation technology; Extraction process optimization; Active ingredients; Antioxidant activity
-
Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity
作者:Sun, Peng;Zhao, Juan;Sha, Gan;Zhou, Yaru;Zhao, Mengfei;Li, Renjian;Kong, Xiaojing;Sun, Qiping;Li, Yun;Li, Ke;Bi, Ruiqing;Yang, Lei;Qin, Ziting;Huang, Wenzheng;Wang, Yin;Yang, Long;Zheng, Lu;Chen, Xiao-Lin;Li, Guotian;Gao, Jie;Chen, Guang;Li, Qiang;Zhang, Haifeng;Adnan, Muhammad;Wang, Guanghui;Ishikawa, Toshiki;Xu, Jin-Rong;Zhao, Juan;Sha, Gan
关键词:alexidine dihydrochloride; lipid metabolism; mitophagy; pathogenesis; Pyricularia oryzae
-
Enhancing the potential of rapeseed cake as protein-source food by γ-irradiation
作者:Xiong, Chuan;Huang, Wenli;Zhu, Yu;Zou, Xin;Phan, Chia-Wei;Zhu, Yu
关键词: