Generation and evaluation of a genetically attenuated Newcastle disease virus rGM-VIIm as a genotype-matched vaccine

文献类型: 外文期刊

第一作者: Sun, Minhua

作者: Sun, Minhua;Xiang, Bin;Li, Yaling;Xie, Peng;Gao, Shimin;Kang, Yinfeng;Gao, Pei;Li, Yanling;Wang, Zhaoxiong;Liang, Jianpeng;Yu, Deshui;Ren, Tao;Sun, Minhua;Xiang, Bin;Li, Yaling;Xie, Peng;Gao, Shimin;Kang, Yinfeng;Gao, Pei;Li, Yanling;Wang, Zhaoxiong;Liang, Jianpeng;Yu, Deshui;Ren, Tao;Sun, Minhua;Xiang, Bin;Li, Yaling;Xie, Peng;Gao, Shimin;Kang, Yinfeng;Gao, Pei;Li, Yanling;Wang, Zhaoxiong;Liang, Jianpeng;Yu, Deshui;Ren, Tao;Sun, Minhua;Xiang, Bin;Li, Yaling;Xie, Peng;Gao, Shimin;Kang, Yinfeng;Gao, Pei;Li, Yanling;Wang, Zhaoxiong;Liang, Jianpeng;Yu, Deshui;Ren, Tao;Sun, Minhua;Gao, Shimin;Kang, Yinfeng;Wang, Zhaoxiong

作者机构:

关键词: Newcastle disease virus;Genotype VII;Reverse genetics;Vaccine

期刊名称:VIRUS GENES ( 影响因子:2.332; 五年影响因子:2.0 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Despite intensive vaccination campaigns, outbreaks of Newcastle disease (ND) have been frequently reported in China, especially of genotype VII that first emerged in the late 1990s. Given the dire need for vaccines against the circulating genotype VII virus, we developed an alternative method to recover a highly virulent recombinant GM (rGM) virus that involves a T7 system with a hammerhead ribozyme sequence introduced downstream of the T7 promoter. By changing the F-0 polybasic cleavage site RRQKRa dagger"F to the monobasic GRQGRa dagger"L, we generated a mutant virus (rGM-VIIm) that was found to be highly attenuated in chickens. The rGM-VIIm virus not only produced fourfold higher hemagglutination assay (HA) titers than the parental virus, but also exhibited genetic stability after 15 continuous passages in specific-pathogen-free (SPF) embryonated eggs. Whether live or inactivated, rGM-VIIm and LaSota vaccines can protect vaccinated birds from GM challenge infection. However, live and inactivated rGM-VIIm vaccines reduced virus shedding of the homologous challenge virus significantly better than the LaSota virus vaccine did. Altogether, our results suggest that rGM-VIIm vaccines could aid in the control of ND in China.

分类号: R37

  • 相关文献

[1]Development of a reverse genetics system based on RNA polymerase II for Newcastle disease virus genotype VII. Wang, Jianzhong,Yin, Renfu,Cong, Yanlong,Ding, Zhuang,Wang, Chunfeng,Feng, Na,Wang, Hualei,Zheng, Xuexing,Yang, Songtao,Gao, Yuwei,Xia, Xianzhu,Liu, Xiufan,Hu, Shunlin,Ding, Chan,Yu, Shengqing.

[2]The deletion of an extra six nucleotides in the 5 '-untranslated region of the nucleoprotein gene of Newcastle disease virus NA-1 decreases virulence. Liu, Jiaxu,Cong, Yanlong,Yin, Renfu,Ding, Zhuang,Wang, Chunfeng,Wang, Chunfeng,Ding, Chan,Yu, Shengqing,Liu, Xiufan. 2014

[3]Rescue of virulent class I Newcastle disease virus variant 9a5b-D5C1. Yu, Yang,Qiu, Xusheng,Xu, Dan,Zhan, Yuan,Meng, Chunchun,Wei, Nana,Chen, Hongjun,Tan, Lei,Yu, Shengqing,Ding, Chan,Ding, Chan,Yu, Yang,Liu, Xiufan,Qin, Aijian. 2012

[4]Generation by reverse genetics of an effective attenuated Newcastle disease virus vaccine based on a prevalent highly virulent Chinese strain. Liu, Meng-Meng,Cheng, Jin-Long,Yu, Xiao-Hui,Zhang, Guo-Zhong,Qin, Zhuo-Ming,Tian, Fu-Lin.

[5]A reassortment vaccine candidate as the improved formulation to induce protection against very virulent infectious bursal disease virus. Qi, Xiaole,Chen, Yuming,Ren, Xiangang,Zhang, Lizhou,Gao, Li,Wang, Nian,Qin, Liting,Wang, Yongqiang,Gao, Yulong,Wang, Xiaomei. 2014

[6]A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum. Sun, Yun,Sun, Li,Liu, Chun-sheng,Sun, Yun.

[7]Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: Subunit vaccine vs DNA vaccine. Sun, Yun,Sun, Li,Sun, Yun,Liu, Chun-Sheng.

[8]Porcine reproductive and respiratory syndrome virus as a vector: Immunogenicity of green fluorescent protein and porcine circovirus type 2 capsid expressed from dedicated subgenomic RNAs. Du, Yijun,Song, Cheng,Yoo, Dongwan,Pei, Yanlong,Hodgins, Douglas C.,Wu, Jiaqiang,Song, Cheng,Welch, Siao-Kun W.,Calvert, Jay G.,Li, Gang. 2009

[9]An improved method for infectious bursal disease virus rescue using RNA polymerase II system. Qi, Xiaole,Gao, Wong,Gao, Honglei,Deng, Xiaoyun,Bu, Zhigao,Wang, Xiaoyan,Fu, Chaoyang,Wang, Xiaomei. 2007

[10]Development of a tailored vaccine against challenge with very virulent infectious bursal disease virus of chickens using reverse genetics. Gao, Li,Qi, Xiaole,Li, Kai,Gao, Honglei,Gao, Yulong,Qin, Liting,Wang, Yongqiang,Wang, Xiaomei. 2011

[11]Infective viruses produced from full-length complementary DNA of swine vesicular disease viruses HK/70 strain. Zheng Haixue,Liu Xinagtao,Shang Youjun,Wu Jinyan,Bai Xingwen,Jin Ye,Sun Shiqi,Guo Huichen,Tian Hong,Feng Xia,Yin Shaunghui,Guo Jianhong,Cong Guozheng,Liu Zaixin,Chang Huiyun,Ma Junwu,Xie Qingge.

[12]Efficacy of a high-yield attenuated vaccine strain wholly derived from avian influenza viruses by use of reverse genetics. Liu, Ming,Liu, Ming.

[13]Alternative reverse genetics system for influenza viruses based on a synthesized swine 45S rRNA promoter. Wang, Kai,Huang, Qi,Yang, Zhiwei,Qi, Kezong,Chen, Hongjun,Wang, Kai,Huang, Qi,Yang, Zhiwei,Liu, Hongmei,Chen, Hongjun.

[14]Protective efficacy of a high-growth reassortant swine H3N2 inactivated vaccine constructed by reverse genetic manipulation. Wen, Feng,Ma, Ji-Hong,Yu, Hai,Yang, Fu-Ru,Huang, Meng,Zhou, Yan-Jun,Li, Ze-Jun,Tong, Guang-Zhi.

[15]Functional analysis of GUS expression patterns and T-DNA integration characteristics in rice enhancer trap lines. Peng, H,Huang, HM,Yang, YZ,Zhai, Y,Wu, JX,Huang, DF,Lu, TG.

[16]Recovery of infectious type Asia1 foot-and-mouth disease virus from suckling mice directly inoculated with an RNA polymerase I/II-driven unidirectional transcription plasmid. Lian, Kaiqi,Yang, Fan,Zhu, Zixiang,Cao, Weijun,Jin, Ye,Li, Dan,Zhang, Keshan,Guo, Jianhong,Zheng, Haixue,Liu, Xiangtao.

[17]Rapid Recovery of Classical Swine Fever Virus Directly from Cloned cDNA. Huang Jun-hua,Li Yong-feng,He Fan,Li Dan,Sun Yuan,Han Wen,Qiu Hua-ji. 2013

[18]Characterization of a pathogenic full-length cDNA clone of a virulent porcine epidemic diarrhea virus strain AH2012/12 in China. Fan, Baochao,Yu, Zhengyu,Pang, Fengjiao,Xu, Xiangwei,Zhang, Baimeng,Guo, Rongli,He, Kongwang,Li, Bin,Fan, Baochao,Yu, Zhengyu,Pang, Fengjiao,Xu, Xiangwei,Zhang, Baimeng,Guo, Rongli,He, Kongwang,Li, Bin.

[19]Progress of reverse genetics technique in influenza virus. Liu Da-Fei,Liu Chun-Guo,Liu Ming,Liu Da-Cheng. 2008

[20]Host Innate Immune Responses of Ducks Infected with Newcastle Disease Viruses of Different Pathogenicities. Kang, Yinfeng,Li, Yanling,Yuan, Runyu,Feng, Minsha,Xiang, Bin,Sun, Minhua,Li, Yaling,Xie, Peng,Tan, Yangtong,Ren, Tao,Kang, Yinfeng,Li, Yanling,Yuan, Runyu,Feng, Minsha,Xiang, Bin,Sun, Minhua,Li, Yaling,Xie, Peng,Tan, Yangtong,Ren, Tao,Kang, Yinfeng,Li, Yanling,Feng, Minsha,Xiang, Bin,Ren, Tao,Yuan, Runyu,Sun, Minhua. 2015

作者其他论文 更多>>