Structural Characterization of Inclusion Complex of Hesperidin Methyl Chalcone and Hydroxypropyl-beta-cyclodextrin

文献类型： 外文期刊

第一作者： Li, Yun

作者： Li, Yun;Li, Fang;Sun, Wei;Chen, Xuan;Shen, Wangyang;Li, Fang;Shen, Wangyang

作者机构：

关键词： Hesperidin methyl chalcone;Hydroxypropyl-beta-cyclodextrin;Inclusion complex;Physicochemical property

期刊名称：JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN （ 影响因子：0.536； 五年影响因子：0.585 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Hesperidin methyl chalcone (HMC) was a semisynthetic derivative of hesperidin, which owned antiviral and antimicrobial activities. Owing these properties, it can be applied in pharmaceutical industry. However low stability had become a barrier to its application. In order to overcome this problem, an inclusion complex of hesperidin methyl chalcone and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were prepared by freeze-drying, using some analytical techniques to characterize the inclusion complex, including ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). The results of these analytical techniques indicated that the hesperidin methyl chalcone has been dispersed completely in the HP-beta-CD without a new compound formed, but entrapped inside the cavity of HP-beta-CD.

分类号： O6

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