A Phenylselenium-Substituted BODIPY Fluorescent Turn-off Probe for Fluorescence Imaging of Hydrogen Sulfide in Living Cells

文献类型： 外文期刊

第一作者： Gong, Deyan

作者： Gong, Deyan;Deng, Min;Iqbal, Anam;Liu, Weisheng;Qin, Wenwu;Gong, Deyan;Deng, Min;Iqbal, Anam;Liu, Weisheng;Qin, Wenwu;Zhu, Xiangtao;Han, Shi-Chong;Guo, Huichen;Zhu, Xiangtao;Han, Shi-Chong;Guo, Huichen;Tian, Yuejun

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期刊名称：ANALYTICAL CHEMISTRY （ 影响因子：6.986； 五年影响因子：6.755 ）

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收录情况： SCI

摘要： Herein a phenylselenium-substituted BODIPY (1) fluorescent turn-off sensor was developed for the purpose to achieve excellent selectivity and sensitivity for H2S detection based on the substitution reaction of the phenylselenide group at the 3-position with H2S. The excess addition of hydrogen sulfide promoted further substitution of the phenylselenide group at the 5-position of the probe and was accompanied by a further decrease in fluorescence emission intensity. Sensor 1 demonstrated remarkable performance with 49-fold red color fluorescence intensity decrease at longer excitation wavelength, a low detection limit (0.0025 mu M), and specific fluorescent response toward H2S over anions, biothiols, and other amino acids in neutral media. It showed no obvious cell toxicity and good membrane permeability, which was well exploited for intracellular H2S detection and imaging through fluorescence microscopy imaging.

分类号： O65

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